13 Papers
44 Citations
Meetu Gupta is an academic researcher from Institute of Genomics and Integrative Biology. The author has contributed to research in topics: Phosphorylation & Protein kinase A. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of Meetu Gupta include University of Delhi & Council of Scientific and Industrial Research.
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Papers
Bacterial Virulence Factors: Secreted for Survival
Aditya K. Sharma,Aditya K. Sharma,Neha Dhasmana,Neha Dhasmana,Neha Dubey,Nishant Kumar,Nishant Kumar,Aakriti Gangwal,Meetu Gupta,Yogendra Singh,Yogendra Singh +10 more
TL;DR: The role of some of the secreted virulence factors of two human pathogens: Mycobacterium tuberculosis—an intracellular pathogen and Bacillus anthracis—an extracellular pathogenic are revisited.
Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP is regulated by phosphorylation
Andaleeb Sajid,Gunjan Arora,Meetu Gupta,Anshika Singhal,Kausik Chakraborty,Vinay Kumar Nandicoori,Yogendra Singh +6 more
TL;DR: The results show that the modulation of the MtbEf-Tu-GTP interaction by phosphorylation can have an impact on cellular protein synthesis and growth and suggest that the efficacy of an inhibitor can also depend on the posttranslational modification of the target and should be considered during the development of the molecule.
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Understanding the Role of PknJ in Mycobacterium tuberculosis: Biochemical Characterization and Identification of Novel Substrate Pyruvate Kinase A
Gunjan Arora,Andaleeb Sajid,Meetu Gupta,Asani Bhaduri,Pawan Kumar,Sharmila Basu-Modak,Yogendra Singh +6 more
TL;DR: This study focuses on previously uncharacterized Mycobacterium tuberculosis Ser/Thr protein kinase (STPK) PknJ, a putative transmembrane protein that is shown to possess autophosphorylation activity and to be capable of carrying out phosphorylation on the artificial substrate myelin basic protein (MyBP).
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Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB.
Andaleeb Sajid,Gunjan Arora,Meetu Gupta,Sandeep Upadhyay,Vinay Kumar Nandicoori,Yogendra Singh +5 more
TL;DR: It is shown that the lone Ser/Thr phosphatase (PstP) is regulated through phosphorylation by STPKs, and the results indicate that ST PKs and PstP may regulate the signaling through mutually dependent mechanisms.
Attack on the scourge of tuberculosis: patented drug targets.
TL;DR: This review presents a comprehensive account of the pivotal information for drug discovery and drug design to all researchers involved in tuberculosis research, and enlist drug targets against M. tuberculosis for which patents have been filed and issued during the last ten years.
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