Meenu R. Pillai
St. Jude Children's Research Hospital
15 Papers
67 Citations
Meenu R. Pillai is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Biology & T cell. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Meenu R. Pillai include University of Leicester.
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Papers
Dynamic regulatory network controlling Th17 cell differentiation
Nir Yosef,Alex K. Shalek,Jellert T. Gaublomme,Hulin Jin,Youjin Lee,Amit Awasthi,Amit Awasthi,Chuan Wu,Katarzyna Karwacz,Sheng Xiao,Marsela Jorgolli,David Gennert,Rahul Satija,Arvind Shakya,Diana Lu,John J. Trombetta,Meenu R. Pillai,Peter J. Ratcliffe,Mathew L. Coleman,Mark Bix,Dean Tantin,Hongkun Park,Hongkun Park,Vijay K. Kuchroo,Vijay K. Kuchroo,Aviv Regev,Aviv Regev +26 more
TL;DR: This study identifies and validates 39 regulatory factors, embeds them within a comprehensive temporal network and reveals its organizational principles; it also highlights novel drug targets for controlling TH17 cell differentiation.
The Development and Function of Regulatory T Cells
Creg J. Workman,Andrea L. Szymczak-Workman,Lauren W. Collison,Meenu R. Pillai,Dario A. A. Vignali +4 more
TL;DR: The development of natural and induced T Regs are discussed as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression are discussed.
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Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner.
TL;DR: Surprisingly, Treg were able to mediate potent suppression of Tconv across a permeable membrane when placed in direct contact with Tconv in the upper chamber of a Transwell plate, suggesting that it is the induction of suppression, rather than the function of Treg that is obligatorily contact dependent.
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Enhanced Susceptibility of Ago1/3 Double-Null Mice to Influenza A Virus Infection
Melanie Van Stry,Thomas H. Oguin,Sihem Cheloufi,Peter Vogel,Makiko Watanabe,Meenu R. Pillai,Pradyot Dash,Paul G. Thomas,Gregory J. Hannon,Gregory J. Hannon,Mark Bix +10 more
TL;DR: The results support the notion that the enhanced flu susceptibility of double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation.
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Nek2B stimulates zygotic centrosome assembly in Xenopus laevis in a kinase-independent manner.
Ciara Twomey,Samantha L. Wattam,Meenu R. Pillai,Joseph Rapley,Joanne E. Baxter,Andrew M. Fry +5 more
TL;DR: It is shown that addition of either active or kinase-dead recombinant Nek2B can restore centrosome assembly in a dose-dependent manner to a depleted extract, and this results support a model in which maternal Nek1B acts to promote assembly of a functional zygoticCentrosome in a Kinase-independent manner.
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