Mazène Hochane
Leiden University
15 Papers
39 Citations
Mazène Hochane is an academic researcher from Leiden University. The author has contributed to research in topics: Parathyroid hormone-related protein & Biology. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Mazène Hochane include University of Strasbourg & French Institute of Health and Medical Research.
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Papers
Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.
Mazène Hochane,Patrick R. van den Berg,Xueying Fan,Noémie M. L. P. Bérenger-Currias,Esmée Adegeest,Monika Bialecka,Maaike Nieveen,Maarten Menschaart,Susana M. Chuva de Sousa Lopes,Susana M. Chuva de Sousa Lopes,Stefan Semrau +10 more
TL;DR: A single-cell transcriptomics study of the human fetal kidney is presented, identifying 22 cell types and a host of marker genes and exploring the heterogeneity of the nephrogenic niche, localized podocyte precursors, and confirmed disease-associated marker genes.
155
Deciphering Metabolic Heterogeneity by Single-Cell Analysis.
Tom M J Evers,Mazène Hochane,Sander J. Tans,Ron M. A. Heeren,Stefan Semrau,Peter Nemes,Alireza Mashaghi +6 more
TL;DR: This feature highlights recent developments in key analytical techniques suited for single-cell metabolic analysis with a special focus on mass spectrometry-based analytical platforms and RNA-seq, as well as imaging techniques that reveal stochasticity in metabolism.
116
Targeting FAK scaffold functions inhibits human renal cell carcinoma growth
Claire Béraud,Valérian Dormoy,Sabrina Danilin,Véronique Lindner,Audrey Bethry,Mazène Hochane,Catherine Coquard,Mariette Barthelmebs,Didier Jacqmin,Hervé Lang,Thierry Massfelder +10 more
TL;DR: The findings reveal a previously uncharacterized role of FAK in CCC whereby FAK exerts oncogenic properties through a non canonical signaling pathway involving its scaffolding kinase‐independent properties, and targeting the FAK scaffold may represent a promising approach for developing innovative and highly specific therapies in human CCC.
36
Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure
Denis Raison,Denis Raison,Catherine Coquard,Catherine Coquard,Mazène Hochane,Mazène Hochane,Jacques Steger,Jacques Steger,Thierry Massfelder,Thierry Massfelder,B. Moulin,Andrew C. Karaplis,Daniel Metzger,Daniel Metzger,Pierre Chambon,Pierre Chambon,Jean-Jacques Helwig,Jean-Jacques Helwig,Mariette Barthelmebs,Mariette Barthelmebs +19 more
TL;DR: Findings show that endogenous vascular smooth muscle PTHrP controls renal hemodynamics under basal conditions, and it is an essential factor in renal vasodilation elicited by saline volume expansion.
29
Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC.
Mazène Hochane,Valérie Trichet,Valérie Trichet,Claire Pecqueur,Pierre Avril,Pierre Avril,Lisa Oliver,Jérôme Alexandre Denis,Régis Brion,Jérôme Amiaud,Jérôme Amiaud,Alain Pineau,Philippe Naveilhan,Dominique Heymann,François M. Vallette,Christophe Olivier +15 more
TL;DR: It is suggested that a common combination of pesticides can induce a premature ageing of adult MSC, and as such could accelerate age‐related diseases.