Mayuko Uehara
Brigham and Women's Hospital
51 Papers
72 Citations
Mayuko Uehara is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 13, co-authored 44 publications. Previous affiliations of Mayuko Uehara include Sapporo Medical University.
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Papers
Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation
Jose Marino,Mohamed H. Babiker-Mohamed,Patrick Crosby-Bertorini,J.T. Paster,Christian LeGuern,Sharon Germana,Reza Abdi,Mayuko Uehara,James I. Kim,James F. Markmann,Georges Tocco,Gilles Benichou +11 more
TL;DR: Results suggest that recipient antigen-presenting cells cross-dressed with donor MHC rather than passenger leukocytes trigger T cell responses after allotransplantation, and stresses the need for selective immune-based therapies relying on manipulation of lymphocyte recognition of donor antigens.
Targeted Delivery of Immunomodulators to Lymph Nodes
Jamil Azzi,Qian Yin,Mayuko Uehara,Shunsuke Ohori,Li Tang,Kaimin Cai,Takaharu Ichimura,Martina M. McGrath,Omar H. Maarouf,Eirini Kefaloyianni,Scott Loughhead,Jarolim Petr,Qidi Sun,Mincheol Kwon,Stefan G. Tullius,Ulrich H. von Andrian,Ulrich H. von Andrian,Jianjun Cheng,Reza Abdi +18 more
TL;DR: It is shown that targeted lymph node delivery of microparticles containing tacrolimus can prolong heart allograft survival with negligible changes in tacolimus serum level.
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Targeting antigen-presenting cells by anti–PD-1 nanoparticles augments antitumor immunity
Farideh Ordikhani,Mayuko Uehara,Vivek Kasinath,Li Dai,Siawosh K. Eskandari,Baharak Bahmani,Merve Yonar,Jamil Azzi,Yousef Haik,Peter T. Sage,George F. Murphy,Nasim Annabi,Tobias Schatton,Indira Guleria,Reza Abdi +14 more
TL;DR: It is found that anti-PD-1 NPs undergo internalization by DCs in the spleen, leading to their maturation and the subsequent activation of T cells, which improves the antitumor effect of this agent in the B16-F10 murine melanoma model.
Ischemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity.
Mayuko Uehara,Zhabiz Solhjou,Naima Banouni,Vivek Kasinath,Ye Xiaqun,Li Dai,Osman A. Yilmam,Mine Yilmaz,Takaharu Ichimura,Paolo Fiorina,Paulo N. Martins,Shunsuke Ohori,Indira Guleria,Omar H. Maarouf,Stefan G. Tullius,Martina M. McGrath,Reza Abdi +16 more
TL;DR: A novel pathway where IRI activates innate immunity, leading to upregulation of antigen specific alloimmunity, resulting in chronic allograft injury is described, and a clinically relevant treatment strategy to overcome the deleterious effect of IRI is described.
Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation.
Xiaofei Li,Xiaofei Li,Jing Zhao,Vivek Kasinath,Mayuko Uehara,Liwei Jiang,Naima Banouni,Martina M. McGrath,Takaharu Ichimura,Paolo Fiorina,Dario R. Lemos,Dario R. Lemos,Su Ryon Shin,Carl F. Ware,Jonathan S. Bromberg,Reza Abdi +15 more
TL;DR: It is demonstrated that the transformation of FRCs into proinflammatory myofibroblasts is critically important for the maintenance of a proinflammatory milieu within a fibrotic DLN.