Mayada Achour
University of Strasbourg
12 Papers
92 Citations
Mayada Achour is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Jurkat cells & Gene. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Mayada Achour include Centre national de la recherche scientifique.
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Papers
The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?
Christian Bronner,Mayada Achour,Yoshimi Arima,Thierry Chataigneau,Hideyuki Saya,Valérie B. Schini-Kerth +5 more
TL;DR: The physiological roles played by the UHRF family are most likely exerted during embryogenic development and when proliferation is required in adults, and some new roles are proposed, including regulation and/or inheritance of the epigenetic code.
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Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.
Mahmoud Alhosin,Abdurazzag Abusnina,Mayada Achour,Tanveer Sharif,Christian D. Muller,Jean Peluso,Thierry Chataigneau,Claire Lugnier,Valérie B. Schini-Kerth,Christian Bronner,Guy Fuhrmann +10 more
TL;DR: The results showed that TQ mediates its growth inhibitory effects on ALL p53-mutated cells via the activation of a p73-dependent mitochondrial and cell cycle checkpoint signaling pathway which subsequently targets UHRF1.
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Neuronal Identity Genes Regulated by Super-Enhancers Are Preferentially Down-Regulated in the Striatum of Huntington's Disease Mice
Mayada Achour,Stéphanie Le Gras,Céline Keime,Frédéric Parmentier,François-Xavier Lejeune,Anne-Laurence Boutillier,Christian Neri,Irwin Davidson,Karine Merienne +8 more
TL;DR: Striatal super-enhancers display extensive H3K27 acetylation within gene bodies, drive transcription characterized by low levels of paused RNAPII, regulate neuronal function genes and are enriched in binding motifs for Gata transcription factors, such as Gata2 regulating striatal identity genes.
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Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.
Mayada Achour,Marc Mousli,Mahmoud Alhosin,Abdulkhaleg Ibrahim,Jean Peluso,Christian D. Muller,Valérie B. Schini-Kerth,Ali Hamiche,Sirano Dhe-Paganon,Christian Bronner +9 more
TL;DR: It is shown that EGCG down-regulates UHRF1 and DNMT1 expression in Jurkat cells, with subsequent up-regulation of p73 and p16(INK4A) genes.
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Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1
Tanveer Sharif,Cyril Auger,Mahmoud Alhosin,Claudine Ebel,Mayada Achour,Nelly Etienne-Selloum,Guy Fuhrmann,Christian Bronner,Valérie B. Schini-Kerth +8 more
TL;DR: Findings indicate that RWPs induce apoptosis in Jurkat cells by a redox-sensitive mechanism involving the intracellular formation of superoxide anions and consequently the up-regulation of p73 and down- regulation of UHRF1.
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