Maya Vinzing
Charité
5 Papers
129 Citations
Maya Vinzing is an academic researcher from Charité. The author has contributed to research in topics: Biology & Gene silencing. The author has an hindex of 4, co-authored 4 publications.
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Papers
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
Bastian Opitz,Amira Rejaibi,Bianca Dauber,Jamina Eckhard,Maya Vinzing,Bernd Schmeck,Stefan Hippenstiel,Norbert Suttorp,Thorsten Wolff +8 more
TL;DR: It is demonstrated that infection of epithelial cells with NS1‐deficient influenza A virus upregulated expression of two molecules that have been previously implicated in sensing of RNA viruses, the retinoic acid‐inducible gene I (RIG‐I) and the melanoma differentiation‐associated gene 5 (MDA5).
293
Legionella pneumophila Induces IFNβ in Lung Epithelial Cells via IPS-1 and IRF3, Which Also Control Bacterial Replication
Bastian Opitz,Maya Vinzing,Vincent van Laak,Bernd Schmeck,Guido Heine,Stefan Günther,Robert Preissner,Hortense Slevogt,Philippe Dje N′Guessan,Julia Eitel,Torsten Goldmann,Antje Flieger,Norbert Suttorp,Stefan Hippenstiel +13 more
TL;DR: A critical role of IPS-1, IRF3, and IFNβ in Legionella infection of lung epithelium is demonstrated and bacterial multiplication assays in small interfering RNA-treated cells indicated that IPS- 1, IRFs 3, andIFNβ were essential for the control of intracellular replication of L. pneumophila in lung epithelial cells.
134
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper
Tong-Yuan Yang,Manuela Braun,Wibke Lembke,Fraser McBlane,John Kamerud,Stephen DeWall,Edit Tarcsa,Xiao-Fen Fang,Lena Hofer,Uma Kavita,Vijay V. Upreti,Swati Gupta,Lina Loo,Alison J. Johnson,Rakesh K. Chandode,Kay Stubenrauch,Maya Vinzing,Cindy Q. Xia,Vibha Jawa +18 more
TL;DR: In this paper , the authors present bioanalytical strategies, methodologies, and assay validation applied to appropriately monitor immunogenicity in AAV gene therapy-treated subjects, and summarize the risks and their impact in nonclinical and clinical studies, and various clinical mitigation strategies.
68
TLR2- and Nucleotide-Binding Oligomerization Domain 2-Dependent Krüppel-Like Factor 2 Expression Downregulates NF-κB–Related Gene Expression
Janine Zahlten,Robert Steinicke,Bastian Opitz,Julia Eitel,Philippe Dje N'Guessan,Maya Vinzing,Martin Witzenrath,Bernd Schmeck,Sven Hammerschmidt,Norbert Suttorp,Stefan Hippenstiel +10 more
TL;DR: KLF2 may act as a counterregulatory transcription factor in pneumococci- and pattern recognition receptor-related proinflammatory activation of lung cells, thereby preventing lung hyperinflammation and subsequent organ failure.
26
NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells
Maya Vinzing,Julia Eitel,Juliane Lippmann,Andreas C. Hocke,Janine Zahlten,Hortense Slevogt,Philippe Dje N'Guessan,Stefan Günther,Bernd Schmeck,Stefan Hippenstiel,Antje Flieger,Norbert Suttorp,Bastian Opitz +12 more
TL;DR: It is demonstrated that flagellin-deficient L. pneumophila replicate more efficiently in human THP-1 macrophage, primary monocyte-derived macrophages, and alveolar macrophaging, and in A549 lung epithelial cells compared with wild-type bacteria.