Maya Ketzef
Ben-Gurion University of the Negev
11 Papers
58 Citations
Maya Ketzef is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Epileptogenesis & Biology. The author has an hindex of 6, co-authored 7 publications.
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Papers
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures
David Gilad,Sharon Shorer,Maya Ketzef,Alon Friedman,Israel Sekler,Elias Aizenman,Michal Hershfinkel +6 more
TL;DR: It is suggested that mZnR/GPR39-dependent upregulation of KCC2 activity provides homeostatic adaptation to an excitotoxic stimulus by increasing inhibition, and may provide a novel pharmacological target for dampening epileptic seizure activity.
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Differential TGF-β Signaling in Glial Subsets Underlies IL-6–Mediated Epileptogenesis in Mice
Nitzan Levy,Dan Z. Milikovsky,Gytis Baranauskas,Ekaterina Vinogradov,Yaron David,Maya Ketzef,Shai Abutbul,Itai Weissberg,Lyn Kamintsky,Ilya A. Fleidervish,Alon Friedman,Alon Friedman,Alon Monsonego +12 more
TL;DR: The data suggest that TGF-β signaling in the brain can cause astrocyte activation whereby IL-6 upregulation results in dysregulation of astroCyte–neuronal interactions and neuronal hyperexcitability, as well as in FVB/N mice characterized as a relatively more susceptible strain to seizure-induced cell death.
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Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.
TL;DR: It is suggested that while deletion of the synapsins initially increases cortical network activity, this enhanced excitability is insufficient to elicit seizures, and compensatory epileptogenic mechanisms are activated during the latent period that lead to an additional almost-balanced enhancement of both the excitatory and inhibitory components of the network, finally culminating in the emergence of epilepsy.
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Epileptic Synapsin Triple Knockout Mice Exhibit Progressive Long-Term Aberrant Plasticity in the Entorhinal Cortex
Maya Ketzef,Daniel Gitler +1 more
TL;DR: Although congenital impairments in inhibitory transmission may initiate epileptogenesis in the synapsin TKO mice, it is suggested that secondary adaptations are crucial for the establishment of this epileptic network.
16
Sensory responses in dorsolateral striatum are modulated by motor activity in a dopamine-dependent manner
TL;DR: The results show that sensory responses in basal ganglia circuits are modulated by motor activity and that both processes are dopamine- and cell type-dependent.
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