Maya Hammami
University of Marburg
10 Papers
83 Citations
Maya Hammami is an academic researcher from University of Marburg. The author has contributed to research in topics: Matriptase & Protease. The author has an hindex of 7, co-authored 10 publications.
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Papers
Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses
Joanna Baron,Carolin Tarnow,Deborah Mayoli-Nüssle,Eva Schilling,Daniela Meyer,Maya Hammami,Folker Schwalm,Torsten Steinmetzer,Yi Guan,Wolfgang Garten,Hans-Dieter Klenk,Eva Böttcher-Friebertshäuser +11 more
TL;DR: Proteolytic activation of early H9N2 isolate A/turkey/Wisconsin/1/66 (H9-Wisc) and two recent Asian isolates, containing mono-, di-, and tribasic HA cleavage sites, demonstrate that H 9N2 viruses with R-S-S/R-R cleavage Sites are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues
142
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.
Daniela Meyer,Frank Sielaff,Maya Hammami,Eva Böttcher-Friebertshäuser,Wolfgang Garten,Torsten Steinmetzer +5 more
TL;DR: A series of new fluorogenic substrates containing a D-arginine residue at the P3 position was synthesized, some of them were efficiently cleaved by TMPRSS2 and showed an efficient blockage of influenza virus propagation in human airway epithelial cells.
130
Identification of the first low-molecular-weight inhibitors of matriptase-2.
Mihiret T. Sisay,Torsten Steinmetzer,Marit Stirnberg,Eva Maurer,Maya Hammami,Jürgen Bajorath,Michael Gütschow +6 more
TL;DR: A comparative three-dimensional model of the catalytic domain of matriptase-2 was generated and utilized for structure-based virtual screening in combination with similarity searching and knowledge-based compound design, and two N-protected dipeptide amides containing a 4-amidinobenzylamide as P1 residue were identified.
72
Changing the Selectivity Profile - From Substrate Analog Inhibitors of Thrombin and Factor Xa to Potent Matriptase Inhibitors
Alexander Maiwald,Maya Hammami,Sebastian Wagner,Andreas Heine,Gerhard Klebe,Torsten Steinmetzer +5 more
TL;DR: New noncovalent substrate-analogs with superior potency against matriptase are prepared from previously described nonspecific thrombin and factor Xa inhibitors and the most suitable compound 35 (H-d-hTyr-Ala-4-amidinobenzylamide) binds to matriptases with an inhibition constant of 26 nM and has more than 10-fold reduced activity.
9
Patent
Use of tmprss2 inhibitors as medicaments
Torsten Steinmetzer,Daniela Meyer,Maya Hammami,Frank Sielaff,Wolfgang Garten,Eva Böttcher-Friebertshäuser +5 more
- 20 Jul 2012
TL;DR: In this article, the use of inhibitors according to general formula I for treating viral infections, in particular for treating influenza infections, for the treatment of inflammatory respiratory tract diseases or for inhibiting serine protease TMPRSS2, wherein X represents CH or N, R 1 represents a substituted cyclic sulfonyl radical, R 2 represents a non-substituted or substituted amidino group and R 3 represents a secondary amide group coupled as an amide.
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