Maxwell Wheeler

TL;DR: This work developed a sample preparation methodology for enzymatic lysis and sample heating for low-resource, point-of-care applications and demonstrated that both DNA and RNA in the heat-treated sample could be directly amplified without purification, even in the presence of a clinically-obtained human nasal sample.

TL;DR: In this article, the authors describe a sample assessment device that includes a substrate including a sample application region, an amplification region comprising a plurality of amplification reagents, a waste region comprising an entrance fluidically coupled to the amplification region, and a detection region spaced apart from the amplification regions.

TL;DR: In this paper, the authors present a capillarity-based device for performing chemical processes and associated system and methods, which can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element, and wherein, when both the first and second fluid sources are in fluid connection with input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

TL;DR: In this paper, the authors present a technique for stopping-flow microfluidic devices with a first porous element configured to receive a first fluid and a second porous element configurable to receive another fluid.