Maxine Gowen
University of Sheffield
88 Papers
1.7K Citations
Maxine Gowen is an academic researcher from University of Sheffield. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 46, co-authored 88 publications.
Chat about Author
Papers
Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization.
Maxine Gowen,Francesca Lazner,R.A. Dodds,Rasesh Kapadia,John A. Feild,Michael Tavaria,Ivan Bertoncello,F. Drake,Silva Zavarselk,Irene Tellis,Paul J. Hertzog,Christine Debouck,Ismail Kola +12 more
TL;DR: Close histologic examination of bone histology revealed fully differentiated osteoclasts apposed to small regions of demineralized bone, which strongly suggests that cathepsin K–deficient osteoclast are capable ofdemineralizing the extracellular matrix but are unable to adequately remove the deminERALized bone.
521
Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance
Jonathan D. Violin,Scott M. DeWire,Dennis S. Yamashita,David H. Rominger,Lisa Nguyen,Kevin Schiller,Erin J. Whalen,Maxine Gowen,Michael W. Lark +8 more
TL;DR: The discovery of a potent, selective β-arrestin biased ligand of the angiotensin II type 1 receptor validated the use of biased ligands to selectively target specific receptor functions in drug discovery.
373
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
Maxine Gowen,George B. Stroup,R.A. Dodds,Ian E. James,Bart J. Votta,Brian R. Smith,Pradip K. Bhatnagar,Lago Amparo M,James F. Callahan,Eric G. Delmar,Michael A. Miller,Edward F. Nemeth,John Fox +12 more
TL;DR: It is demonstrated that an increase in endogenous PTH secretion, induced by antagonism of the parathyroid cell Ca(2+) receptor with a small molecule, leads to a dramatic increase in bone turnover, and it is suggested that a novel approach to the treatment of osteoporosis is suggested.
295
Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro.
TL;DR: The results suggest that interleukin 1 has activities upon non-immune cells which promote the degradation of connective tissue matrices.
293
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.
Dennis Lee,Scott A. Long,Jerry L. Adams,George K. Chan,Kalindi Vaidya,Terry A. Francis,Kristine Kikly,James D. Winkler,Chiu-Mei Sung,Christine Debouck,Susan B. Richardson,Mark Alan Levy,Walter E. DeWolf,Paul M. Keller,Thaddeus A. Tomaszek,Martha S. Head,Ryan M Dominic,R. Curtis Haltiwanger,Po-Huang Liang,Cheryl A. Janson,Patrick McDevitt,Kyung O. Johanson,Nestor O. Concha,Winnie Chan,Sherin S. Abdel-Meguid,Alison M. Badger,Michael W. Lark,Daniel P. Nadeau,Larry J. Suva,Maxine Gowen,Mark E. Nuttall +30 more
TL;DR: The inhibition of apoptosis and maintenance of cell functionality with a caspase 3/7-selective inhibitor is demonstrated for the first time, and suggests that targeting these two caspases alone is sufficient for blocking apoptosis.
250