Maxime Killer
Stowers Institute for Medical Research
5 Papers
4 Citations
Maxime Killer is an academic researcher from Stowers Institute for Medical Research. The author has contributed to research in topics: Biology & Transporter. The author has an hindex of 2, co-authored 3 publications.
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Papers
Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network
Mark K. Adams,Charles A.S. Banks,Janet L. Thornton,Cassandra G. Kempf,Ying Zhang,Sayem Miah,Yan Hao,Mihaela E. Sardiu,Maxime Killer,Gaye Hattem,Alexis Murray,Maria L. Katt,Laurence Florens,Michael P. Washburn,Michael P. Washburn +14 more
TL;DR: It is shown that Sin3 paralog identity influences complex composition and chemical cross-linking MS identifies domains that mediate interactions between Sin3 proteins and binding partners, and the characterization of rare SIN3B proteoforms provides additional evidence for the existence of conserved and divergent elements within human Sin3protein.
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Purification and enzymatic assay of class I histone deacetylase enzymes.
TL;DR: This chapter presents an optimized workflow for the isolation of recombinant protein and subsequent assay of class I HDAC activity, and demonstrates the application of this assay by assessing the activities of recombination HDAC1, HDAC2, and SIN3B.
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Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition
Vadim Kotov,Maxime Killer,Katharina E. J. Jungnickel,Jian Lei,Giada Finocchio,Josi Steinke,Kim Bartels,Jan Strauss,Florine Dupeux,Anne-Sophie Humm,Irina Cornaciu,José A. Márquez,Els Pardon,Jan Steyaert,Christian Löw +14 more
TL;DR: In this article , the authors present 14 X-ray structures of the bacterial POT DtpB in complex with chemically diverse di- and tripeptides, providing novel insights into the plasticity of the conserved central binding cavity.
Differential complex formation via paralogs in the human Sin3 protein interaction network
Mark K. Adams,Charles A.S. Banks,Janet L. Thornton,Mihaela E. Sardiu,Maxime Killer,Cassandra G. Kempf,Laurence Florens,Michael P. Washburn,Michael P. Washburn +8 more
TL;DR: It is found that paralog switching influences the interaction networks of the Sin3 complexes and sheds light on the shared and divergent properties of human Sin3 proteins and highlights the heterogeneous nature of the complexes they organize.
Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C
Maxime Killer,Giada Finocchio,Haydyn D. T. Mertens,Dmitri I. Svergun,Els Pardon,Jan Steyaert,Christian Löw +6 more
TL;DR: This work provides a molecular explanation for the selectivity of DtpC, and highlights the value of small and rigid fiducial markers such as nanobodies for structure determination of low molecular weight integral membrane proteins lacking soluble domains.