Automatic Classification of 10 Blood Cell Subtypes using Transfer Learning via Pre-Trained Convolutional Neural Networks

Abstract Digital in-line holographic microscopy (DIHM) is a non-invasive, real-time, label-free technique that captures three-dimensional (3D) positional, orientational, and morphological information from digital holographic images of living biological cells. Unlike conventional microscopies, the DIHM technique enables precise measurements of dynamic behaviors exhibited by living cells within a 3D volume. This review outlines the fundamental principles and comprehensive digital image processing procedures employed in DIHM-based cell tracking methods. In addition, recent applications of DIHM technique for label-free identification and digital tracking of various motile biological cells, including human blood cells, spermatozoa, diseased cells, and unicellular microorganisms, are thoroughly examined. Leveraging artificial intelligence has significantly enhanced both the speed and accuracy of digital image processing for cell tracking and identification. The quantitative data on cell morphology and dynamics captured by DIHM can effectively elucidate the underlying mechanisms governing various microbial behaviors and contribute to the accumulation of diagnostic databases and the development of clinical treatments. 

pdf/digital-in-line-holographic-microscopy-for-label-free-47lpwe11em.pdf

Digital in-line holographic microscopy for label-free identification and tracking of biological cells

While LLMs have demonstrated impressive performance across various domains and tasks, their security issues have become increasingly severe. Machine unlearning (MU) has emerged as a promising solution to address these issues by removing the influence of undesired data on the target model without compromising its utility in other aspects. MU typically assumes full access to the original training data to preserve utility, which is difficult to achieve in LLM unlearning. Existing LLM unlearning methods often assume access to data most affected by undesired data unlearning. However, this assumption underestimates the entanglement among various LLM capabilities and ignores data access limitations due to various issues. Moreover, these LLM unlearning methods do not sufficiently consider that unlearning requests in real-world scenarios are continuously emerging. To overcome these challenges and achieve practical LLM unlearning, we propose the O3 framework. The O3 framework includes an Out-Of-Distribution (OOD) detector to measure the similarity between input and unlearning data, and an Orthogonal low-rank adapter (LoRA) for continuously unlearning requested data. The OOD detector is trained with a novel contrastive entropy loss and utilizes a local-global layer-aggregated scoring mechanism. The orthogonal LoRA achieves parameter disentanglement among continual unlearning requests. During inference, our O3 framework can smartly decide whether and to what extent to load the unlearning LoRA based on the OOD detector's predictions. Notably, O3's effectiveness does not rely on any retained data. We conducted extensive experiments on O3 and state-of-the-art LLM unlearning methods across three tasks and seven datasets. The results indicate that O3 consistently achieves the best trade-off between unlearning effectiveness and utility preservation, especially when facing continuous unlearning requests. 

pdf/practical-unlearning-for-large-language-models-qk25u08kjb.pdf

Practical Unlearning for Large Language Models

Hematology is the study of diagnosis and treatment options for blood diseases, including cancer. Cancer is considered one of the deadliest diseases across all age categories. Diagnosing such a deadly disease at the initial stage is essential to cure the disease. Hematologists and pathologists rely on microscopic evaluation of blood or bone marrow smear images to diagnose blood-related ailments. The abundance of overlapping cells, cells of varying densities among platelets, non-illumination levels, and the amount of red and white blood cells make it more difficult to diagnose illness using blood cell images. Pathologists are required to put more effort into the traditional, time-consuming system. Nowadays, it becomes possible with machine learning and deep learning techniques, to automate the diagnostic processes, categorize microscopic blood cells, and improve the accuracy of the procedure and its speed as the models developed using these methods may guide an assisting tool. In this article, we have acquired, analyzed, scrutinized, and finally selected around 57 research papers from various machine learning and deep learning methodologies that have been employed in the diagnosis of leukemia and its classification over the past 20 years, which have been published between the years 2003 and 2023 by PubMed, IEEE, Science Direct, Google Scholar and other pertinent sources. Our primary emphasis is on evaluating the advantages and limitations of analogous research endeavors to provide a concise and valuable research directive that can be of significant utility to fellow researchers in the field. 

Hematologic cancer diagnosis and classification using machine and deep learning: State-of-the-art techniques and emerging research directives.

Proprietary and closed APIs are becoming increasingly common to process natural language, and are impacting the practical applications of natural language processing, including few-shot classification. Few-shot classification involves training a model to perform a new classification task with a handful of labeled data. This paper presents three contributions. First, we introduce a scenario where the embedding of a pre-trained model is served through a gated API with compute-cost and data-privacy constraints. Second, we propose a transductive inference, a learning paradigm that has been overlooked by the NLP community. Transductive inference, unlike traditional inductive learning, leverages the statistics of unlabeled data. We also introduce a new parameter-free transductive regularizer based on the Fisher-Rao loss, which can be used on top of the gated API embeddings. This method fully utilizes unlabeled data, does not share any label with the third-party API provider and could serve as a baseline for future research. Third, we propose an improved experimental setting and compile a benchmark of eight datasets involving multiclass classification in four different languages, with up to 151 classes. We evaluate our methods using eight backbone models, along with an episodic evaluation over 1,000 episodes, which demonstrate the superiority of transductive inference over the standard inductive setting.

pdf/transductive-learning-for-textual-few-shot-classification-in-4tr7bjmhmm.pdf

Transductive Learning for Textual Few-Shot Classification in API-based Embedding Models

As more and more conversational and translation systems are deployed in production, it is essential to implement and to develop effective control mechanisms guaranteeing their proper functioning and security. An essential component to ensure safe system behavior is out-of-distribution (OOD) detection, which aims at detecting whether an input sample is statistically far from the training distribution. Although OOD detection is a widely covered topic in classification tasks, it has received much less attention in text generation. This paper addresses the problem of OOD detection for machine translation and dialog generation from an operational perspective. Our contributions include: (i) RAINPROOF a Relative informAItioN Projection ODD detection framework; and (ii) a more operational evaluation setting for OOD detection. Surprisingly, we find that OOD detection is not necessarily aligned with task-specific measures. The OOD detector may filter out samples that are well processed by the model and keep samples that are not, leading to weaker performance. Our results show that RAINPROOF breaks this curse and achieve good results in OOD detection while increasing performance.

pdf/rainproof-an-umbrella-to-shield-text-generators-from-out-of-1i5w0pwm.pdf

Rainproof: An Umbrella To Shield Text Generators From Out-Of-Distribution Data

The fraction of red blood cells adopting a specific motion under low shear flow is a promising inexpensive marker for monitoring the clinical status of patients with sickle cell disease. Its high-throughput measurement relies on the video analysis of thousands of cell motions for each blood sample to eliminate a large majority of unreliable samples (out of focus or overlapping cells) and discriminate between tank-treading and flipping motion, characterizing highly and poorly deformable cells respectively. Moreover, these videos are of different durations (from 6 to more than 100 frames). We present a two-stage end-to-end machine learning pipeline able to automatically classify cell motions in videos with a high class imbalance. By extending, comparing, and combining two state-of-the-art methods, a convolutional neural network (CNN) model and a recurrent CNN, we are able to automatically discard 97% of the unreliable cell sequences (first stage) and classify highly and poorly deformable red cell sequences with 97% accuracy and an F1-score of 0.94 (second stage). Dataset and codes are publicly released for the community. 

/pdf/classification-of-red-cell-dynamics-with-convolutional-and-3ir1jnkv.pdf

Classification of red cell dynamics with convolutional and recurrent neural networks: a sickle cell disease case study

pdf/statistical-deficiency-for-task-inclusion-estimation-r3mpdo8rx60n.pdf

Statistical Deficiency for Task Inclusion Estimation

Assessing the quality of summarizers poses significant challenges. In response, we propose a novel task-oriented evaluation approach that assesses summarizers based on their capacity to produce summaries that are useful for downstream tasks, while preserving task outcomes. We theoretically establish a direct relationship between the resulting error probability of these tasks and the mutual information between source texts and generated summaries. We introduce $\texttt{COSMIC}$ as a practical implementation of this metric, demonstrating its strong correlation with human judgment-based metrics and its effectiveness in predicting downstream task performance. Comparative analyses against established metrics like $\texttt{BERTScore}$ and $\texttt{ROUGE}$ highlight the competitive performance of $\texttt{COSMIC}$. 

COSMIC: Mutual Information for Task-Agnostic Summarization Evaluation

Out-of-distribution (OOD) detection is a rapidly growing field due to new robustness and security requirements driven by an increased number of AI-based systems. Existing OOD textual detectors often rely on an anomaly score (e.g., Mahalanobis distance) computed on the embedding output of the last layer of the encoder. In this work, we observe that OOD detection performance varies greatly depending on the task and layer output. More importantly, we show that the usual choice (the last layer) is rarely the best one for OOD detection and that far better results could be achieved if the best layer were picked. To leverage this observation, we propose a data-driven, unsupervised method to combine layer-wise anomaly scores. In addition, we extend classical textual OOD benchmarks by including classification tasks with a greater number of classes (up to 77), which reflects more realistic settings. On this augmented benchmark, we show that the proposed post-aggregation methods achieve robust and consistent results while removing manual feature selection altogether. Their performance achieves near oracle's best layer performance.

Unsupervised Layer-wise Score Aggregation for Textual OOD Detection

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