Max Ledakis
2 Papers
1 Citations
Max Ledakis is an academic researcher. The author has contributed to research in topics: Hippocampal formation & Cognition. The author has an hindex of 1, co-authored 1 publications.
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Papers
Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns
Silvia Viana da Silva,Matthias G. Haberl,Kshitij Gaur,R Patel,Gautam Narayan,Max Ledakis,Maylin L. Fu,Edward H. Koo,Jill K. Leutgeb,Stefan Leutgeb +9 more
TL;DR: Pathology that is highly localized and limited to presynaptic cells is thus sufficient to cause aberrant firing patterns in postsynaptic neuronal networks, which indicates that disease progression is not only from a spreading molecular pathology but also mediated by progressive physiological dysfunction.
Localized APP expression results in progressive network dysfunction by disorganizing spike timing
Silvia Viana da Silva,Matthias G. Haberl,Kshitij Gaur,Rina Patel,Gautam Narayan,Max Ledakis,Maylin L. Fu,Miguel de Castro Vieira,Edward H. Koo,Jill K. Leutgeb,Stefan Leutgeb +10 more
TL;DR: Highly localized pathology limited to the presynaptic CA3 cells is sufficient to cause aberrant firing patterns in postsynaptic neuronal networks, which indicates that disease progression is not only from spreading pathology but also mediated by progressively advancing physiological dysfunction.