Abstract Polysaccharides are promising biomolecules with lowtoxicity and diverse bioactivities in food processing and clinical drug development. However, an essential prerequisite for their applications is the fine structure characterization. Due to the complexity of polysaccharide structure, partial degradation is a powerful tool for fine structure analysis, which can effectively provide valid information on the structure of backbone and branching glycosidic fragments of complex polysaccharides. This review aims to conclude current methods of partial degradation employed for polysaccharide structural characterization, discuss the molecular mechanisms, and describe the molecular structure and solution properties of degraded polysaccharides. In addition, the effects of polysaccharide degradation on the conformational relationships between the molecular structure and bioactivities, such as antioxidant, antitumor, and immunomodulatory activities, are also discussed. Finally, we summarize the prospects and current challenges for the partial degradation of polysaccharides. This review will be of great value for the scientific elucidation of polysaccharide fine structures and potential applications. 

Exploring the partial degradation of polysaccharides: Structure, mechanism, bioactivities, and perspectives.

Controlled release of curcumin from gelatin hydrogels by the molecular-weight modulation of an oxidized dextran cross-linker

Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review.

Biodegradable dual stimuli responsive alginate based microgels for controlled agrochemicals release and soil remediation.

Dextran dialdehyde (ODex) was added to a nanocomplex of soy protein isolate (SPI)-curcumin (Cur) to improve its stability and achieve controlled release of Cur. The SPI-to-ODex mass ratio was optimized to achieve excellent properties and stability. Interactions between various components were confirmed by spectroscopic analysis, and the effect of ODex on the stability and bioactivity of SPI-Cur colloids was discussed. ODex was found to be crosslinked with SPI via the Schiff base reaction, which increased the ζ-potential and improved the surface hydrophobicity of nanocomplexes. At a SPI-to-ODex mass ratio of 20:1, the nanocomplex had a smaller particle size (199.2 nm), higher ζ-potential (−45.48 mV), and higher encapsulation efficiency (96.25%). Furthermore, adding ODex changed the network structure and effectively improved the thermal and storage stability of Cur as well as its antioxidant properties. Moreover, controlled release of Cur was observed during simulated digestion in the gastrointestinal environment. 

Oxidized dextran improves the stability and effectively controls the release of curcumin loaded in soybean protein nanocomplexes.

Periodate oxidation of plant polysaccharides provides polysaccharide-specific oligosaccharides.

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Periodate oxidation of plant polysaccharides provides polysaccharide-specific oligosaccharides.