Mattias Ögren
Uppsala University
88 Papers
633 Citations
Mattias Ögren is an academic researcher from Uppsala University. The author has contributed to research in topics: Crystal structure & Copper. The author has an hindex of 18, co-authored 84 publications.
Chat about Author
Papers
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant.
Mats Bergström,Richard Hargreaves,H. Donald Burns,Michael R. Goldberg,David G. Sciberras,Scott A. Reines,Kevin J. Petty,Mattias Ögren,Gunnar Antoni,Bengt Långström,Olli Eskola,Mika Scheinin,Olof Solin,Anup K. Majumdar,M.L Constanzer,Wendy P Battisti,Thomas E. Bradstreet,Cynthia Gargano,Jarmo Hietala +18 more
TL;DR: Positron emission tomography imaging with [(18)F]SPA-RQ allows brain NK( 1) receptor occupancy by aprepitant to be predicted from plasma drug concentrations and can be used to guide dose selection for clinical trials of NK(1) receptor antagonists in central therapeutic indications.
208
The Effect of Hydrogen Bonding on the Structures of Uracil and Some Methyl Derivatives Studied by Experiment and Theory.
Compounds labelled with short-lived beta(+)-emitting radionuclides and some applications in life sciences. The importance of time as a parameter.
Bengt Långström,Tor Kihlberg,Mats Bergström,Gunnar Antoni,Margareta Björkman,Benita H. Forngren,Tobias Forngren,Per Hartvig,Karin E. Markides,Ulrika Yngve,Mattias Ögren +10 more
TL;DR: Some examples of recent development of the synthesis of compounds labelled with short-lived beta(+)-emitting radionuclides will be discussed with an emphasis on the importance of time in selecting a synthetic strategy.
Receptor imaging technique with 11C-labeled receptor ligands in living brain slices: its application to time-resolved imaging and saturation analysis of benzodiazepine receptor using [11C]Ro15-1788.
Tetsuhito Murata,Kiyoshi Matsumura,Hirotaka Onoe,Mats Bergström,Hajime Takechi,Sven Sihver,Wiebke Sihver,Henrik Neu,Yvonne Andersson,Mattias Ögren,Karl Johan Fasth,Bengt Långström,Yasuyoshi Watanabe +12 more
TL;DR: The present method, for the first time, made it possible to study a ligand-receptor interaction in living brain slices with temporal and spatial resolutions and should prove useful for studies of receptor function under physiological conditions.
31