Matthieu Colom
Claude Bernard University Lyon 1
5 Papers
Matthieu Colom is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 2, co-authored 3 publications.
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Papers
18 F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT 1A receptor agonist for PET neuroimaging
Benjamin Vidal,Sylvain Fieux,Matthieu Colom,Thierry Billard,Caroline Bouillot,Olivier Barret,Cristian Constantinescu,Gilles Tamagnan,Adrian Newman-Tancredi,Luc Zimmer +9 more
TL;DR: 18F-F13640 is a 5-HT1A receptor agonist with a high affinity and a high selectivity that would be suitable for a potential PET radiopharmaceutical and Quantification analyses with kinetic modeling are in progress to prepare the first-in-man study of F13640.
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[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations
Matthieu Colom,Benjamin Vidal,Sylvain Fieux,Jérôme Redouté,Nicolas Costes,Franck Lavenne,Inés Mérida,Zacharie Irace,Thibaud Iecker,Caroline Bouillot,Thierry Billard,Adrian Newman-Tancredi,Luc Zimmer +12 more
TL;DR: In this article, Colom et al. showed that 5-HT 1A Brain Imaging and Fenfluramine data underline the need to perform longer PET scan to ensure accurate measure of displacement, they support clinical development of [18 F]F13640 as a tool to explore experimental paradigms involving physiological or pathological (neurological or neuropsychiatric pathologies) fluctuations of extracellular serotonin.
[18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
Pierre Courault,Sophie Lancelot,Nicolas Costes,Matthieu Colom,D. Le Bars,Jérôme Redouté,Florent Gobert,Frédéric Dailler,Sibel Isal,Thibaut Iecker,Adrian Newman-Tancredi,Inés Mérida,Luc Zimmer +12 more
TL;DR: In this paper , the authors characterized brain labeling of 5-HT 1A receptors by F13640 in humans and described a simplified model for its quantification, which showed high uptake values in raphe nuclei and cortical regions.
18F-F13640 PET imaging of functional receptors in humans.
Matthieu Colom,Nicolas Costes,Jérôme Redouté,Frédéric Dailler,Florent Gobert,Didier Le Bars,Thierry Billard,Adrian Newman-Tancredi,Luc Zimmer +8 more
TL;DR: F-F13640 is the first radiopharmaceutical that enables in vivo investigation of functional 5-HT1A receptors that are likely to be altered in pathological conditions such as neurodegenerative diseases or psychiatric disorders and opens new opportunities for nuclear medicine.
Detection of ISUP ≥2 prostate cancers using multiparametric MRI: prospective multicentre assessment of the non-inferiority of an artificial intelligence system as compared to the PI-RADS V.2.1 score (CHANGE study)
Olivier Rouvière,Rémi Souchon,Carole Lartizien,Adeline Mansuy,Laurent Magaud,Matthieu Colom,Marine Dubreuil-Chambardel,Sabine Debeer,Tristan Jaouen,Audrey Duran,Pascal Rippert,Benjamin Riche,Caterina Monini,Virginie Vlaeminck-Guillem,Julie Haesebaert,Muriel Rabilloud,Sebastien Crouzet +16 more
TL;DR: The study primary objective is to evaluate the non-inferiority of the area under the receiver operating characteristic curve of the final CAD system as compared with the Prostate Imaging-Reporting and Data System V.2.1 in predicting the presence of ISUP ≥2 prostate cancer in patients undergoing prostate biopsy.