Matthias Sammer
Bundeswehr University Munich
20 Papers
3 Citations
Matthias Sammer is an academic researcher from Bundeswehr University Munich. The author has contributed to research in topics: Irradiation & Chemistry. The author has an hindex of 6, co-authored 10 publications.
Chat about Author
Papers
DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage
Thomas Friedrich,K. Ilicic,Christoph Greubel,Stefanie Girst,Judith Reindl,Matthias Sammer,Benjamin Schwarz,Christian Siebenwirth,Christian Siebenwirth,Dietrich W. M. Walsh,Thomas E. Schmid,Michael Scholz,Günther Dollinger +12 more
TL;DR: This work investigates the spatial extension of DNA lesion patterns causing cell inactivation using focused spots of ionizing radiation as damaging agent and finds that clustering of DNA damage on both the nm and µm scale leads to enhanced inactivation compared to more homogeneous lesion distributions.
Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation.
Annique C. Dombrowsky,Jannis Schauer,Matthias Sammer,Andreas Blutke,Dietrich W. M. Walsh,Dietrich W. M. Walsh,Dietrich W. M. Walsh,Benjamin Schwarz,Stefan Bartzsch,Annette Feuchtinger,Judith Reindl,Stephanie E. Combs,Günther Dollinger,Thomas E. Schmid +13 more
TL;DR: The parameter of ear thickness can be used as an objective, numerical and dose-dependent quantification criterion to characterize the severity of acute toxicity and allow for the prediction of late effects.
20
Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model.
Matthias Sammer,Katharina Teiluf,Stefanie Girst,Christoph Greubel,Judith Reindl,K. Ilicic,Dietrich W. M. Walsh,Dietrich W. M. Walsh,Michaela Aichler,Axel Walch,Stephanie E. Combs,Jan J. Wilkens,Günther Dollinger,Thomas E. Schmid +13 more
TL;DR: The gradual increase of radiation toxicity with beam size shows that also larger beams are capable of healthy tissue sparing in spatial fractionation.
Local inhibition of rRNA transcription without nucleolar segregation after targeted ion irradiation of the nucleolus.
Christian Siebenwirth,Christian Siebenwirth,Christoph Greubel,Guido A. Drexler,Judith Reindl,Dietrich W. M. Walsh,Benjamin Schwarz,Matthias Sammer,Iris Baur,Helmut Pospiech,Thomas E. Schmid,Günther Dollinger,Anna A. Friedl +12 more
TL;DR: The presented data indicate that even multiple complex DSBs do not lead to a pan-n nucleolar response if they affect only a subnucleolar region, and only locally inhibits rRNA transcription, but does not cause nucleolar segregation.
Proton-FLASH: effects of ultra-high dose rate irradiation on an in-vivo mouse ear model
Sarah Rudigkeit,Thomas E. Schmid,Annique C. Dombrowsky,Jessica Stolz,S. Bartzsch,Ce-Belle Chen,Nicole Matejka,Matthias Sammer,A. Bergmaier,G. Dollinger,Judith Reindl +10 more
TL;DR: An estimation of the irradiated blood volume demonstrates, that 100-times more blood is irradiated when using Conv compared to using Flash9 or Flash930, indicating that blood might play a role in the underlying mechanisms in the protective effect of FLASH.
10