Matthew W. Mitchell
Durham University
38 Papers
126 Citations
Matthew W. Mitchell is an academic researcher from Durham University. The author has contributed to research in topics: Metabolomics & Metabolome. The author has an hindex of 24, co-authored 32 publications.
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Papers
Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems.
TL;DR: A platform that integrated the chemical analysis, including identification and relative quantification, data reduction, and quality assurance components of the process enabled the high-throughput collection and relative quantitative analysis of analytical data and identified a large number and broad spectrum of molecules with a high degree of confidence.
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Analysis of the adult human plasma metabolome.
Kay A. Lawton,Alvin Berger,Matthew W. Mitchell,K. Eric Milgram,Anne M. Evans,Lining Guo,Richard W. Hanson,Richard W. Hanson,Satish C. Kalhan,John A. Ryals,Michael V. Milburn +10 more
TL;DR: Age-associated changes were more pronounced than those related to differences in sex or race in the population group the authors studied, and those that were found to be statistically altered with age, sex orRace were found.
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High Resolution Mass Spectrometry Improves Data Quantity and Quality as Compared to Unit Mass Resolution Mass Spectrometry in High- Throughput Profiling Metabolomics
Anne M. Evans,Brandi Bridgewater,Liu Q,Matthew W. Mitchell,Risa J. Robinson,Dai H,Stewart Sj,DeHaven Cd,Miller Lad +8 more
TL;DR: In this paper, the analytical attributes of a high resolution accurate mass (HRAM) orbitrap based mass spectrometer compared to a unit mass resolution (UMR) ion-trap mass analyzer were evaluated for high-throughput, non-targeted metabolomics.
Discovery of Metabolomics Biomarkers for Early Detection of Nephrotoxicity
Kurt J. Boudonck,Matthew W. Mitchell,László Német,Lilla Keresztes,Abraham Nyska,Doron Shinar,Moti Rosenstock +6 more
TL;DR: A panel of biomarkers useful for early identification of nephrotoxicity may provide a noninvasive method to detect kidney injury long before the onset of histopathological kidney damage.
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Acceleration of Purine Degradation by Periodontal Diseases
Virginia Barnes,Ricardo Teles,H.M. Trivedi,William DeVizio,Tao Xu,Matthew W. Mitchell,Michael V. Milburn,Lining Guo +7 more
TL;DR: An unbiased metabolomic profiling of gingival crevicular fluid collected from healthy, gingivitis, and periodontitis sites in humans suggests that periodontal-disease-induced oxidative stress and inflammation are mediated through this pathway.
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