Matthew Smith
Lawson Health Research Institute
6 Papers
112 Citations
Matthew Smith is an academic researcher from Lawson Health Research Institute. The author has contributed to research in topics: Alzheimer's disease & Stroop effect. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Matthew Smith include University of Western Ontario.
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Papers
Reduced hippocampal glutamate in Alzheimer disease
Raul Rupsingh,Michael Borrie,Michael Borrie,Matthew Smith,Jennie Wells,Jennie Wells,Robert Bartha +6 more
TL;DR: Compared hippocampal metabolite levels between normal elderly controls (NEC) and subjects with MCI and AD, decreased hippocampal Glu may be an indicator of AD.
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High field 1H MRS of the hippocampus after donepezil treatment in Alzheimer disease
Robert Bartha,Matthew Smith,Raul Rupsingh,Jane Rylett,Jennie Wells,Jennie Wells,Michael Borrie,Michael Borrie +7 more
TL;DR: The reduced levels of N-acetylaspartate in AD patients indicates continued decline in neuronal function and/or integrity, however decreased levels of choline and myo-inositol/creatine ratio may indicate a positive treatment effect.
52
Metabolic markers of cobalamin deficiency and cognitive function in normal older adults.
TL;DR: This study aims to investigate the relationship between metabolic markers of cobalamin deficiency and cognitive function in normal older adults and to establish a causal link between these markers and disease-related decline in older adults.
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Treatment effect size of memantine therapy in Alzheimer disease and vascular dementia.
TL;DR: The most convincing evidence of a clinically meaningful treatment effect of memantine therapy is in the moderate-severe AD patient population, and it is shown that cognition, as measured by the Severe Impairment Battery, had a small-to-medium effect of the medication.
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P-052: Changes in brain ventricle volume associated with mild cognitive impairment and Alzheimer disease in subjects participating in the Alzheimer’s disease neuroimaging initiative (ADNI)
Sean M. Nestor,Raul Rupsingh,Vittorio Accomazzi,Michael Borrie,Matthew Smith,Jennie Wells,Robert Bartha +6 more
TL;DR: The brain regions showing positive structural and functional correlations with CA1 volume in this study are consistent with the known projections of CA1 and thus provide in vivo validation of the method for subfield quantification.
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