Matthew L. Williams
University of Louisville
48 Papers
326 Citations
Matthew L. Williams is an academic researcher from University of Louisville. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 22, co-authored 41 publications. Previous affiliations of Matthew L. Williams include Harvard University & Duke University.
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Papers
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium
Patrick Most,Sven T. Pleger,Mirko Völkers,Beatrix Heidt,Melanie Boerries,Dieter Weichenhan,Eva Löffler,Paul M.L. Janssen,Andrea D. Eckhart,Jeffrey S. Martini,Matthew L. Williams,Hugo A. Katus,Andrew Remppis,Walter J. Koch +13 more
TL;DR: It is demonstrated that restoration of S100A1 protein levels in failing myocardium by gene transfer may be a novel therapeutic strategy for the treatment of heart failure.
Survival Prognosis and Surgical Management of Ischemic Mitral Regurgitation
Carmelo A. Milano,Mani A. Daneshmand,J. Scott Rankin,Emily F. Honeycutt,Matthew L. Williams,Madhav Swaminathan,Lauren Linblad,Linda K. Shaw,Donald D. Glower,Peter K. Smith +9 more
TL;DR: In patients with moderate and severe IMR, repair achieved 93.7% of full survival potential; valve replacement was less satisfactory, primarily owing to higher operative mortality.
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Targeted β-Adrenergic Receptor Kinase (βARK1) Inhibition by Gene Transfer in Failing Human Hearts
Matthew L. Williams,Jonathan A. Hata,Jacob N. Schroder,Edward N. Rampersaud,Jason A. Petrofski,Andre Jakoi,Carmelo A. Milano,Walter J. Koch +7 more
TL;DR: Results demonstrate that as in animal models of HF, expression of the &bgr;ARKct can improve contractile function and &b gr;-adrenergic responsiveness in failing human myocytes, and may represent a therapeutic strategy for human HF.
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Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization.
TL;DR: The most abundant cardiac GRK, known as GRK2 or beta AR kinase 1 (beta ARK1), is increased in human HF, and has been implicated in the pathogenesis of dysfunctional cardiac beta AR signaling as mentioned in this paper.
91
Current outcomes for tricuspid valve infective endocarditis surgery in North America.
Jeffrey G. Gaca,Shubin Sheng,Mani A. Daneshmand,J. Scott Rankin,Matthew L. Williams,Sean M. O'Brien,James S. Gammie +6 more
TL;DR: Isolated TV operation for IE is a rare clinical entity with a similar operative mortality to left-sided IE operations, and patients in the healed TV IE group demonstrated lower complication rates, length of stay, and a trend toward decreased mortality.
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