Matthew L. Freedman
Harvard University
305 Papers
2.9K Citations
Matthew L. Freedman is an academic researcher from Harvard University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 67, co-authored 266 publications. Previous affiliations of Matthew L. Freedman include Massachusetts Institute of Technology & University of Texas MD Anderson Cancer Center.
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Papers
Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors
Sarah Abou Alaiwi,Amin Nassar,Amin Nassar,Wanling Xie,Ziad Bakouny,Jacob E. Berchuck,David A. Braun,Sylvan C. Baca,Pier Vitale Nuzzo,Pier Vitale Nuzzo,Ronan Flippot,Ronan Flippot,Tarek H. Mouhieddine,Liam F. Spurr,Yvonne Y. Li,Taiwen Li,Taiwen Li,Abdallah Flaifel,John A. Steinharter,Claire A. Margolis,Natalie I. Vokes,Heng Du,Sachet A. Shukla,Andrew D. Cherniack,Guru Sonpavde,Robert I. Haddad,Mark M. Awad,Marios Giannakis,F. Stephen Hodi,X. Shirley Liu,Sabina Signoretti,Cigall Kadoch,Matthew L. Freedman,David J. Kwiatkowski,Eliezer M. Van Allen,Toni K. Choueiri +35 more
TL;DR: It is found that there is not a consistent association between mSWI/SNF LOF variants and improved clinical outcomes to ICIs, suggesting that m SWI/ SNF variants should not be considered as biomarkers of response to ICI response.
Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation
Caiyong Chen,Daniel Garcia-Santos,Yuichi Ishikawa,Alexandra Seguin,Liangtao Li,Katherine H. Fegan,Gordon J. Hildick-Smith,Darshan Anil Shah,Jeffrey D. Cooney,Wen Chen,Matthew J. King,Yvette Y. Yien,Iman J. Schultz,Heidi Anderson,Abigail Goodnow Dalton,Matthew L. Freedman,Paul D. Kingsley,James Palis,Shilpa M. Hattangadi,Shilpa M. Hattangadi,Shilpa M. Hattangadi,Harvey F. Lodish,Diane M. Ward,Jerry Kaplan,Takahiro Maeda,Prem Ponka,Barry H. Paw +26 more
- 01 Feb 2013
TL;DR: The authors showed that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for proper delivery of iron to erythroid progenitors.
68
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer
Shaghayegh Nouruzi,Dwaipayan Ganguli,Nakisa Tabrizian,Maxim Kobelev,Olena Sivak,Takeshi Namekawa,Daksh Thaper,Sylvan C. Baca,Matthew L. Freedman,Adeleke H. Aguda,Alastair H. Davies,Amina Zoubeidi +11 more
TL;DR: In this paper , the authors identify the proneuronal transcription factor ASCL1 motif to be enriched in hyperaccessible regions, which acts as a driver of the lineage plastic, neuronal transcriptional program to support treatment resistance and neuroendocrine phenotype.
Cis -eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
Kate Lawrenson,Qiyuan Li,Qiyuan Li,Siddhartha Kar,Ji-Heui Seo,Jonathan Tyrer,Tassja J. Spindler,Janet M. Lee,Yi-Bu Chen,Alison M. Karst,Ronny Drapkin,Katja K.H. Aben,Hoda Anton-Culver,Natalia Antonenkova,Helen Baker,Elisa V. Bandera,Yukie Bean,Matthias W. Beckmann,Andrew Berchuck,Maria Bisogna,Line Bjørge,Natalia Bogdanova,Louise A. Brinton,Angela Brooks-Wilson,Angela Brooks-Wilson,Fiona Bruinsma,Ralf Bützow,Ian G. Campbell,Ian G. Campbell,Karen Carty,Jenny Chang-Claude,Georgia Chenevix-Trench,Anne Chen,Zhihua Chen,Linda S. Cook,Daniel W. Cramer,Julie M. Cunningham,Cezary Cybulski,Agnieszka Dansonka-Mieszkowska,Joe Dennis,Ed Dicks,Jennifer A. Doherty,Thilo Dörk,Andreas du Bois,Matthias Dürst,Diana Eccles,Douglas T. Easton,Robert P. Edwards,Ursula Eilber,Arif B. Ekici,Peter A. Fasching,Peter A. Fasching,Brooke L. Fridley,Yu-Tang Gao,Aleksandra Gentry-Maharaj,Graham G. Giles,Graham G. Giles,Rosalind Glasspool,Ellen L. Goode,Marc T. Goodman,Jacek Grownwald,Patricia Harrington,Philipp Harter,Hanis Nazihah Hasmad,Alexander Hein,Florian Heitz,Michelle A.T. Hildebrandt,Peter Hillemanns,Estrid Høgdall,Claus Høgdall,Satoyo Hosono,Edwin S. Iversen,Anna Jakubowska,Paul A. James,Allan Jensen,Bu Tian Ji,Beth Y. Karlan,Susanne K. Kjaer,Linda E. Kelemen,Melissa Kellar,Joseph L. Kelley,Lambertus A. Kiemeney,Camilla Krakstad,Jolanta Kupryjanczyk,Diether Lambrechts,Diether Lambrechts,Sandrina Lambrechts,Nhu D. Le,Alice W. Lee,Shashi Lele,Arto Leminen,Jenny Lester,Douglas A. Levine,Dong Liang,Jolanta Lissowska,Karen Lu,Jan Lubinski,Lene Lundvall,Leon F.A.G. Massuger,Keitaro Matsuo,Valerie McGuire,John R. McLaughlin,Heli Nevanlinna,Ian McNeish,Usha Menon,Francesmary Modugno,Kirsten B. Moysich,Steven A. Narod,Lotte Nedergaard,Roberta B. Ness,Mat Adenan Noor Azmi,Kunle Odunsi,Sara H. Olson,Irene Orlow,Sandra Orsulic,Rachel Palmieri Weber,Celeste Leigh Pearce,Tanja Pejovic,Liisa M. Pelttari,Jennifer Permuth-Wey,Catherine M. Phelan,Malcolm C. Pike,Malcolm C. Pike,Elizabeth M. Poole,Susan J. Ramus,Harvey A. Risch,Barry P. Rosen,Barry P. Rosen,Mary Anne Rossing,Mary Anne Rossing,Joseph H. Rothstein,Anja Rudolph,Ingo B. Runnebaum,Iwona K. Rzepecka,Helga B. Salvesen,Joellen M. Schildkraut,Ira Schwaab,Thomas A. Sellers,Xiao-Ou Shu,Yurii B. Shvetsov,Nadeem Siddiqui,Weiva Sieh,Honglin Song,Melissa C. Southey,Lara Sucheston,Ingvild L. Tangen,Soo Hwang Teo,Kathryn L. Terry,Pamela J. Thompson,Agnieszka Timorek,Ya Yu Tsai,Shelley S. Tworoger,Anne M. van Altena,Els Van Nieuwenhuysen,Ignace Vergote,Robert A. Vierkant,Shan Wang-Gohrke,Christine Walsh,Nicolas Wentzensen,Alice S. Whittemore,Kristine G. Wicklund,Lynne R. Wilkens,Yin Ling Woo,Xifeng Wu,Anna H. Wu,Hannah P. Yang,Wei Zheng,Argyrios Ziogas,Alvaro N.A. Monteiro,Paul D.P. Pharoah,Simon A. Gayther,Matthew L. Freedman,David D.L. Bowtell,Penelope M. Webb,Anna deFazio +174 more
TL;DR: In this article, the authors evaluate the functional role of each candidate by perturbing expression of each gene in HGSOC precursor cells, showing that HOXD9 overexpression increases anchorage-independent growth, shortens population-doubling time and reduces contact inhibition.
Replication of Prostate Cancer Risk Loci in a Japanese Case–Control Association Study
Hiroki Yamada,Kathryn L. Penney,Hiroyuki Takahashi,Takahiko Katoh,Yuko Yamano,Minoru Yamakado,Takahiro Kimura,Hidetoshi Kuruma,Yuko Kamata,Shin Egawa,Matthew L. Freedman +10 more
TL;DR: The results highlight the critical importance of considering ancestry in understanding how risk alleles influence disease and suggest that risk estimates and variants differ across populations.