Matthew Jones
4 Papers
Matthew Jones is an academic researcher. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 2, co-authored 3 publications.
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Papers
Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones
Elena Denisenko,Leanne de Kock,Adeline Tan,Aaron B. Beasley,M. V. Beilin,Matthew Jones,Rui Hou,Daithi O. Muiri,Sanela Bilic,G. R. K. A. Mohan,Stuart Salfinger,Simon Fox,Khaing Pann Witt Hmon,Yen Yeow,Youngmi Kim,Rhea John,Tami S Gilderman,Emily E. Killingbeck,Elin S Gray,Paul A Cohen,Yu Yu,Alistair R R Forrest +21 more
TL;DR: This study highlights the high degree of subclonal heterogeneity in HGSOC and suggests that subclone-specific ligand and receptor expression patterns likely modulate how HGSOC cells interact with their local microenvironment.
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Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution
Marti Cabanes-Creus,Renina Gale Navarro,Sophia H.Y. Liao,Suzanne Scott,Rodrigo Carlessi,Ramon Roca-Pinilla,Maddison Knight,Grober Baltazar,Erhua Zhu,Matthew Jones,Elena Denisenko,Alistair R. R. Forrest,Ian E. Alexander,Janina E.E. Tirnitz-Parker,Leszek Lisowski +14 more
TL;DR: In this article , the authors investigated the validity of a liver xenograft mouse model repopulated with primary hepatocytes using single-nucleus RNA sequencing (sn-RNA-seq) by studying the transcriptomic profile of human hepatocytes pre- and post-engraftment.
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Spatial transcriptomics reveals ovarian cancer subclones with distinct tumour microenvironments
Elena Denisenko,Leanne de Kock,Adeline Tan,Aaron B. Beasley,M. V. Beilin,Matthew Jones,Rui Hou,Daithi O. Muiri,Sanela Bilic,Ganendra R. Mohan,Stuart G. Salfinger,Simon Fox,K. Hmon,Yen Ling Yeow,Elin S. Gray,Paul A. Cohen,Yu Yu,Alistair R. R. Forrest +17 more
TL;DR: It is shown that published HGSOC molecular subtype signatures associated with prognosis are heterogeneously expressed across tumour sections and that areas containing different tumour subclones with different infiltration patterns can match different subtypes.
Functional validation of variants of unknown significance using CRISPR gene editing and transcriptomics: a Kleefstra syndrome case study.
Vanessa S. Fear,Catherine A. Forbes,Denise Anderson,Sebastian Rauschert,Genevieve Syn,Nicolene Shaw,Matthew Jones,Alistair RR Forrest,Gareth Baynam,Timo Lassmann +9 more
TL;DR: In this paper , the application of CRISPR gene editing followed by genome wide transcriptomic profiling to facilitate patient diagnosis is investigated, where a variant in the Euchromatin histone methyl transferase (EHMT1) gene is introduced into HEK293T cells.