Matthew Hackbart
Loyola University Chicago
15 Papers
54 Citations
Matthew Hackbart is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Coronavirus & Virus. The author has an hindex of 6, co-authored 10 publications.
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Papers
Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages.
Xufang Deng,Matthew Hackbart,Robert C. Mettelman,Amornrat O'Brien,Anna M. Mielech,Guanghui Yi,C. Cheng Kao,Susan C. Baker +7 more
TL;DR: It is demonstrated that coronavirus nsp15 is critical for evasion of host dsRNA sensors in macrophages and revealed that modulating nSP15 stability and activity is a strategy for generating live-attenuated vaccines.
363
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors.
TL;DR: The results of this study reveal the PUN RNA to be a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP), and establish a mechanism for EndoU activity to cleave and limit the accumulation of this PAMP.
283
Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages.
Aaron Volk,Matthew Hackbart,Xufang Deng,Yazmin E. Cruz-Pulido,Amornrat O'Brien,Susan C. Baker +5 more
TL;DR: It is found that the EndoUmut virus activates a focused response that predominantly involves type I interferons and interferon-related genes, whereas the WT and DUBmut viruses more broadly stimulate upregulation of over 2,800 genes, including networks associated with activating the unfolded protein response (UPR) and the proinflammatory response associated with viral pathogenesis.
A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease.
Anne H. Rowley,Anne H. Rowley,Susan C. Baker,David Arrollo,Leah J. Gruen,Tetyana Bodnar,Nancy Innocentini,Matthew Hackbart,Yazmin E. Cruz-Pulido,Kristine M. Wylie,Kwang-Youn Kim,Stanford T. Shulman,Stanford T. Shulman +12 more
TL;DR: These results identify a protein epitope targeted by the antibody response to Kawasaki disease and provide a means to elucidate the pathogenesis of this important worldwide pediatric problem.
37
Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.
Xufang Deng,Yafang Chen,Anna M. Mielech,Matthew Hackbart,Kristina R. Kesely,Robert C. Mettelman,Amornrat O'Brien,Mackenzie E. Chapman,Andrew D. Mesecar,Susan C. Baker +9 more
TL;DR: This study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of thePLP2-ubiquitin complex and that PLP2/DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.