Matthew E. Wampole
Thomas Jefferson University
7 Papers
3 Citations
Matthew E. Wampole is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Nucleic acid & RNA. The author has an hindex of 5, co-authored 7 publications.
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Papers
Fluorescence Detection of KRAS2 mRNA Hybridization in Lung Cancer Cells with PNA-Peptides Containing an Internal Thiazole Orange
Mahesh V. Sonar,Matthew E. Wampole,Yuan-Yuan Jin,Chang-Po Chen,Mathew L. Thakur,Eric Wickstrom +5 more
TL;DR: Sequence-specific elevation of internal TO fluorescence is consistent with the hypothesis of detecting cytoplasmic PNA-peptide:RNA hybridization if a mutant agent encounters the corresponding mutant mRNA.
41
Effects of hypoxanthine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: theory and experiment.
Jeffrey M. Sanders,Matthew E. Wampole,Chang-Po Chen,Dalip Sethi,Amrita Singh,François-Yves Dupradeau,Fan Wang,Brian D. Gray,Mathew L. Thakur,Eric Wickstrom +9 more
TL;DR: In this paper, a PNA dodecamer incorporating hypoxanthine, which can form Watson-Crick base pairs with adenine, cytosine, thymine, and uracil, was used for radioimaging of mutant KRAS2 mRNA in tumors in mice.
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Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA
Bishnuhari Paudyal,Kaijun Zhang,Chang-Po Chen,Matthew E. Wampole,Neil Mehta,Edith P. Mitchell,Brian D. Gray,Jeffrey A. Mattis,Koon Y. Pak,Mathew L. Thakur,Eric Wickstrom +10 more
TL;DR: Therapeutic efficacy in malignant breast cancer cells was apparent sooner by molecular PET imaging than by determination of reduction in TV, as indicated by standardized uptake values.
12
Three dimensional projection environment for molecular design and surgical simulation.
Eric Wickstrom,Chang-Po Chen,Devakumar Devadhas,Matthew E. Wampole,Yuan-Yuan Jin,Jeffrey M. Sanders,John C. Kairys,Martha L. Ankeny,Rui Hu,Kenneth E. Barner,Karl V. Steiner,Mathew L. Thakur +11 more
TL;DR: A novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data are created.
2
Consistent surgeon evaluations of three-dimensional rendering of PET/CT scans of the abdomen of a patient with a ductal pancreatic mass.
Matthew E. Wampole,John C. Kairys,Edith P. Mitchell,Martha L. Ankeny,Mathew L. Thakur,Eric Wickstrom +5 more
TL;DR: The experienced surgeons consistently reported positive reactions to 3D surface renderings of fused PET and contrast-enhanced CT scans of a pancreatic cancer and surrounding organs, suggesting the 3D presentation could be a useful preparative tool for surgeons prior to making the first incision.