Matteo Boretto
Katholieke Universiteit Leuven
11 Papers
Matteo Boretto is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Organoid & Biology. The author has an hindex of 8, co-authored 9 publications.
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Papers
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening
Matteo Boretto,Nina Maenhoudt,Xinlong Luo,Aurélie Hennes,Bram Boeckx,Bich Bui,Bich Bui,R. Heremans,Lisa Perneel,Hiroto Kobayashi,Hiroto Kobayashi,Indra Van Zundert,Hilde Brems,Benoit Cox,Marc Ferrante,Hiroshi Uji-i,Kian Peng Koh,Thomas D'Hooghe,Arne Vanhie,Ignace Vergote,Christel Meuleman,Carla Tomassetti,Diether Lambrechts,Joris Vriens,Dirk Timmerman,Hugo Vankelecom +25 more
TL;DR: It is demonstrated that organoids derived from patients with various types of endometrial pathologies can model disease traits and diversity, and can be used as a drug-screening tool.
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Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
Matteo Boretto,Benoit Cox,Manuel Noben,Nikolai Hendriks,Amelie Fassbender,Heleen Roose,Frédéric Amant,Frédéric Amant,Dirk Timmerman,Carla Tomassetti,Arne Vanhie,Christel Meuleman,Marc Ferrante,Hugo Vankelecom +13 more
TL;DR: An organoid culture system for endometrium is established, reproducing tissue epithelium physiology and allowing long-term expansion, and provides a powerful tool for studying mechanisms underlying the biology as well as the pathology of this key reproductive organ.
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Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models.
Nina Maenhoudt,Charlotte Defraye,Matteo Boretto,Ziga Jan,R. Heremans,Bram Boeckx,Florian Hermans,Florian Hermans,Ingrid Arijs,Benoit Cox,Els Van Nieuwenhuysen,Ignace Vergote,Anne-Sophie Van Rompuy,Diether Lambrechts,Dirk Timmerman,Hugo Vankelecom +15 more
TL;DR: Established organoid lines from patient-derived OC showed patient tumor-dependent morphology and disease characteristics, and recapitulated the parent tumor's marker expression and mutational landscape, and displayed tumor-specific sensitivity to clinical HGSOC chemotherapeutic drugs.
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Organoids from pituitary as a novel research model toward pituitary stem cell exploration.
Benoit Cox,Emma Laporte,Annelies Vennekens,Hiroto Kobayashi,Hiroto Kobayashi,Charlotte Nys,Indra Van Zundert,Hiroshi Uji-i,Alizée Vercauteren Drubbel,Benjamin Beck,Heleen Roose,Matteo Boretto,Hugo Vankelecom +12 more
TL;DR: A novel organoid research model is established revealing new insights into the identity and regulation of the putative pituitary stem cells, which may eventually lead to an interesting tool to decipher pituitsary stem cell biology in both healthy and diseased gland.
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Maarten H. Geurts,Shashank Gandhi,Matteo Boretto,Ninouk Akkerman,L. L. Derks,Gijs van Son,Martina Celotti,Sarina Harshuk-Shabso,F. Peci,Harry Begthel,Delilah F. G. Hendriks,Paul Schürmann,Amanda Andersson-Rolf,Susana M. Chuva de Sousa Lopes,J. van Es,Ruben van Boxtel,Hans Clevers +16 more
TL;DR: The application of base editors for the generation of complex tumor models in human ASC-derived organoids is demonstrated and base editor multiplexing allow modeling of colorectal tumorigenesis in a single step by simultaneously transfecting sgRNAs targeting five cancer genes.
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