Matt Simmons
University of Massachusetts Dartmouth
8 Papers
79 Citations
Matt Simmons is an academic researcher from University of Massachusetts Dartmouth. The author has contributed to research in topics: Biofilm & Biofilm matrix. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Matt Simmons include Dartmouth College.
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Papers
MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses
Vanni Bucci,Belinda Tzen,Ning Li,Matt Simmons,Takeshi Tanoue,Elijah Bogart,Luxue Deng,Vladimir Yeliseyev,Mary L. Delaney,Qing Liu,Bernat Olle,Richard R. Stein,Kenya Honda,Lynn Bry,Georg K. Gerber +14 more
TL;DR: MDSINE, a suite of algorithms for inferring dynamical systems models from microbiome time-series data and predicting temporal behaviors, is presented, demonstrating new capabilities, including accurate forecasting of microbial dynamics, prediction of stable sub-communities that inhibit pathogen growth and identification of bacteria most crucial to community integrity in response to perturbations.
Phage mobility is a core determinant of phage-bacteria coexistence in biofilms.
TL;DR: A biofilm simulation framework is developed that captures key mechanistic features of biofilm growth and phage infection and finds that the equilibrium state of interaction between biofilms and phages is governed largely by nutrient availability to biofilm, infection likelihood per host encounter and the ability of phages to diffuse through biofilm populations.
Biofilm structure promotes coexistence of phage-resistant and phage-susceptible bacteria
Matt Simmons,Matthew C. Bond,Britt Koskella,Knut Drescher,Knut Drescher,Vanni Bucci,Vanni Bucci,Carey D. Nadell +7 more
TL;DR: The results provide a clear view into the population dynamics of phage resistance in biofilms with microscopic resolution of the underlying cell-cell and cell-phage interactions and draw an analogy between phage ‘epidemics’ on the sub-millimeter scale of bioFilms and the process of herd immunity studied for decades at much larger spatial scales in populations of plants and animals.
•Journal Article
Hg + の黒体放射シフト,多重極分極率,振動子強度,寿命,超微細定数,及び励起エネルギー
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Theory for the spatiotemporal interaction between lytic phages and biofilm-dwelling bacteria
TL;DR: The first biofilm simulation framework is developed that captures key features of biofilm growth and phage infection and opens avenues to new questions of host-parasite coevolution in the spatially structured biofilm context.