Mathilde Mouchiroud
Laval University
14 Papers
61 Citations
Mathilde Mouchiroud is an academic researcher from Laval University. The author has contributed to research in topics: DEPTOR & Brown adipose tissue. The author has an hindex of 7, co-authored 9 publications.
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Papers
mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.
Sébastien M. Labbé,Mathilde Mouchiroud,Alexandre Caron,Blandine Secco,Elizaveta Freinkman,Lamoureux G,Yves Gélinas,Roger Lecomte,Yohan Bossé,Patricia Chimin,William T. Festuccia,Denis Richard,Mathieu Laplante +12 more
TL;DR: It is shown that cold activates mTORC1 in BAT, an effect that depends on the sympathetic nervous system, and a severe defect in nucleotide synthesis in the absence of m TORC1 is revealed.
Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9
Daniel Agudelo,Sophie Carter,Minja Velimirovic,Alexis Duringer,Jean-François Rivest,Sébastien Lévesque,Jeremy Loehr,Mathilde Mouchiroud,Denis Cyr,Paula J. Waters,Mathieu Laplante,Sylvain Moineau,Adeline Goulet,Yannick Doyon +13 more
TL;DR: It is found that St1Cas9 strain variants enable targeting to five distinct A-rich PAMs and provide a structural basis for their specificities.
Loss of hepatic DEPTOR alters the metabolic transition to fasting
Alexandre Caron,Mathilde Mouchiroud,Nicolas Gautier,Sébastien M. Labbé,Romain Villot,Laurie Turcotte,Blandine Secco,Lamoureux G,Michael Shum,Yves Gélinas,André Marette,Denis Richard,Mathieu Laplante,David M. Sabatini +13 more
- 01 May 2017
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The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.
Mathilde Mouchiroud,Étienne Camiré,Manal Aldow,Alexandre Caron,Éric Jubinville,Laurie Turcotte,Inés Kaci,Marie Josée Beaulieu,Christian Roy,Sébastien M. Labbé,Thibault V. Varin,Yves Gélinas,Jennifer Lamothe,Jocelyn Trottier,Patricia L. Mitchell,Frédéric Guénard,William T. Festuccia,Philippe Joubert,Christopher F. Rose,Constantine J. Karvellas,Olivier Barbier,Mathieu C. Morissette,André Marette,Mathieu Laplante +23 more
TL;DR: It is found that TSK-null mice were not protected against the development of obesity and did not show improvement in glucose tolerance, and the overexpression of TSK failed to modulate thermogenesis, body weight gain, and glucose homeostasis in mice.
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DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance.
Alexandre Caron,Sébastien M. Labbé,Mathilde Mouchiroud,Renaud Huard,Denis Richard,Mathieu Laplante +5 more
TL;DR: Results show that DEPTOR overexpression in POMC neurons does not affect energy balance regulation but could modulate metabolism through a brain-liver connection, and support the idea that other neuronal populations are responsible for these phenotypes.
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