Mathilde Krim

TL;DR: The level of β-interferon in the serum may have limited value as a predictor of antitumor response, toxicity, or biological response modification following i.v. administration, and this schedule of administration can be recommended for further study in Phase II trials.

TL;DR: Although peripheral leukocyte and platelet counts were often decreased by interferon treatment, bone marrow cellularity was generally preserved, and the decrease in peripheral blood counts was not associated with an increased susceptibility to infection or bleeding, which the authors feared might complicate aggressive cytotoxic chemotherapy.

TL;DR: Human lymphoblastoid interferon, at the dose and schedule tested, has minimal antitumor activity as a single agent in advanced colorectal cancer and induces unacceptable toxicity in the majority of such patients.

TL;DR: Treatment of Ehrlich ascites tumor cell cultures in vitro with interferon induces a protein kinase activity that is activated by the polyamines, spermidine and spermine, and unsuccessful attempts to discriminate between these twoprotein kinase activities on the bases of their respective capacities to be activated by either double-stranded RNA or sperMidine/spermine suggest that a single protein kinases enzyme may beactivated by these strikingly dissimilar modifiers.