Mathilde Chivet
University of Trento
6 Papers
3 Citations
Mathilde Chivet is an academic researcher from University of Trento. The author has contributed to research in topics: Androgen receptor & Spinal and bulbar muscular atrophy. The author has an hindex of 5, co-authored 6 publications.
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Papers
Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons.
Karine Laulagnier,Charlotte Javalet,Charlotte Javalet,Fiona J. Hemming,Fiona J. Hemming,Mathilde Chivet,Gaëlle Lachenal,Gaëlle Lachenal,Béatrice Blot,Béatrice Blot,Christine Chatellard,Christine Chatellard,Rémy Sadoul,Rémy Sadoul +13 more
TL;DR: It is shown for the first time that neuronal exosomes may indeed act as vehicles for the intercellular transport of APP and its catabolites.
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Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy
Chiara Scaramuzzino,Ian Casci,Sara Parodi,Sara Parodi,Patricia M.-J. Lievens,Patricia M.-J. Lievens,María José Polanco,María José Polanco,Carmelo Milioto,Carmelo Milioto,Mathilde Chivet,John Monaghan,Ashutosh Mishra,Nisha M. Badders,Tanya Aggarwal,Christopher Grunseich,Fabio Sambataro,Manuela Basso,Frank O. Fackelmayer,J. Paul Taylor,Udai Bhan Pandey,Maria Pennuto,Maria Pennuto +22 more
TL;DR: It is shown here that protein arginine methyltransferase 6 (PRMT6) is a specific co-activator of normal and mutant AR and that the interaction of PRMT6 with AR is significantly enhanced in the AR mutant, which leads to neurodegeneration in cell and fly models of SBMA.
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Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy
María José Polanco,María José Polanco,Sara Parodi,Sara Parodi,Diana Piol,Conor Stack,Mathilde Chivet,Andrea Contestabile,Helen C. Miranda,Patricia M.-J. Lievens,Stefano Espinoza,Tobias Jochum,Anna Rocchi,Christopher Grunseich,Raul R. Gainetdinov,Raul R. Gainetdinov,Andrew C.B. Cato,Andrew P. Lieberman,Albert R. La Spada,Fabio Sambataro,Kenneth H. Fischbeck,Illana Gozes,Maria Pennuto,Maria Pennuto +23 more
TL;DR: Results provide proof of principle that noninvasive therapy based on the use of PACAP analogs is a therapeutic option for SBMA, and develop an analog of pituitary adenylyl cyclase activating polypeptide (PACAP), a potent activator of the AC/PKA pathway.
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Polyglutamine-expanded androgen receptor disrupts muscle triad, calcium dynamics and the excitation-contraction coupling gene expression program
Mathilde Chivet,Caterina Marchioretti,Marco Pirazzini,Diana Piol,Chiara Scaramuzzino,Polanco J,Samir R. Nath,Emanuela Zuccaro,Leonardo Nogara,Marta Canato,Lorenzo Marcucci,Sara Parodi,Romanello,Andrea Armani,Maurizio D'Antonio,Fabio Sambataro,Erik Dassi,Elena Pegoraro,Gianni Sorarù,Carlo Rinaldi,Andrew P. Lieberman,Bert Blaauw,Marco Sandri,Manuela Basso,Maria Pennuto +24 more
TL;DR: It is shown that polyQ-expanded AR alters intrinsic muscle force generation before denervation, revealing an unpredicted role for AR in the regulation of expression of genes involved in muscle contraction and Ca++ dynamics, a level of muscle function regulation that is disrupted in SBMA muscle, yet restored by pharmacologic treatment.
Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
Mathilde Chivet,Charlotte Javalet,Karine Laulagnier,Béatrice Blot,Fiona J. Hemming,Rémy Sadoul +5 more
TL;DR: It is demonstrated for the first time that exosomes released upon synaptic activation do not bind to glial cells but selectively to other neurons suggesting that they can underlie a novel aspect of interneuronal communication.