Mathieu Le Gars
Stanford University
11 Papers
53 Citations
Mathieu Le Gars is an academic researcher from Stanford University. The author has contributed to research in topics: Immune system & CD38. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Mathieu Le Gars include Pasteur Institute.
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Papers
Pregnancy-Induced Alterations in NK Cell Phenotype and Function
Mathieu Le Gars,Christof Seiler,Alexander W. Kay,Nicholas L. Bayless,Elina Starosvetsky,Lindsay Moore,Shai S. Shen-Orr,Natali Aziz,Purvesh Khatri,Cornelia L. Dekker,Gary E. Swan,Mark M. Davis,Susan Holmes,Catherine A. Blish +13 more
TL;DR: It is demonstrated that functional and phenotypic shifts occur in NK cells during pregnancy that can influence the magnitude of the immune response to both infections and tumors.
CytoGLMM: conditional differential analysis for flow and mass cytometry experiments.
Christof Seiler,Christof Seiler,Anne-Maud Ferreira,Lisa M. Kronstad,Lisa M. Kronstad,Laura J. Simpson,Mathieu Le Gars,Elena Vendrame,Catherine A. Blish,Susan Holmes +9 more
TL;DR: In this article, a bootstrapped generalized linear model and a generalized linear mixed model are proposed to find differential proteins in flow and mass cytometry data. But the authors focus on a single cell type and do not consider inter-subject heterogeneity.
Immune Correlates Analysis of a Single Ad26.COV2.S Dose in the ENSEMBLE COVID-19 Vaccine Efficacy Clinical Trial
Youyi Fong,Adrian B. McDermott,David Benkeser,Sanne Roels,Daniel J. Stieh,An Vandebosch,Mathieu Le Gars,Griet A. Van Roey,Christopher R. Houchens,Karen O. Martins,Lakshmi Jayashankar,Flora Castellino,Obrimpong Amoa-Awua,Manjula Basappa,Britta Flach,Bob C. Lin,Christopher I. Moore,M. Naisan,Muhammed Naqvi,Sandeep Narpala,Sarah Oâ Connell,Allen J. Mueller,L. R. Serebryannyy,Mike Castro,Jennifer P. Wang,Christos J. Petropoulos,Alex Luedtke,Olivier Hyrien,Yiwen Lu,Chenchen Yu,Bhavesh Borate,Lars van der Laan,Nima S. Hejazi,Avi Kenny,Marco Carone,Daniel N. Wolfe,Jerald C. Sadoff,Glenda Gray,Beatriz Grinsztejn,Paul A. Goepfert,Susan J. Little,Leonardo Paiva de Sousa,Rebone Maboa,April Kaur Randhawa,Michele P. Andrasik,Jenny Hendriks,Carla Truyers,Frank Struyf,Hanneke Schuitemaker,Macaya Douoguih,James G. Kublin,Lawrence Corey,Kathleen M. Neuzil,Lindsay N. Carpp,Dean Follmann,Peter B. Gilbert,Richard A. Koup,Ruben O. Donis +57 more
TL;DR: Comparison of the vaccine efficacy by ID50 titer curves for ENSEMBLE-US, the COVE trial of the mRNA-1273 vaccine, and the COV002-UK trial ofThe AZD1222 vaccine supported consistency of the ID50Titer correlate of protection across trials and vaccine types.
CD38 contributes to human natural killer cell responses through a role in immune synapse formation
Mathieu Le Gars,Christof Seiler,Alexander W. Kay,Nicholas L. Bayless,Elsa Sola,Elina Starosvetsky,Lindsay Moore,Shai S. Shen-Orr,Natali Aziz,Cornelia L. Dekker,Purvesh Khatri,Gary E. Swan,Mark M. Davis,Susan Holmes,Catherine A. Blish +14 more
TL;DR: It is demonstrated that the cell surface protein CD38 is a key human NK cell functional receptor through a role in immune synapse formation and opens new avenues in immunotherapeutic development for cancer and infection by revealing a critical role for CD38 in NK cell function.
CD38 is a key regulator of enhanced NK cell immune responses during pregnancy through its role in immune synapse formation
Mathieu Le Gars,Christof Seiler,Alexander W. Kay,Nicholas L. Bayless,Elina Starosvetsky,Lindsay Moore,Shai S. Shen-Orr,Natali Aziz,Cornelia L. Dekker,Purvesh Khatri,Gary E. Swan,Mark M. Davis,Susan Holmes,Catherine A. Blish +13 more
TL;DR: Increased CD38 expression directly promotes enhanced NK cell responses during pregnancy through its role in immune synapse formation, which opens new avenues in immunotherapeutic development for cancer and viruses.
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