Mathieu Laplante
Laval University
70 Papers
6K Citations
Mathieu Laplante is an academic researcher from Laval University. The author has contributed to research in topics: Adipose tissue & DEPTOR. The author has an hindex of 34, co-authored 61 publications. Previous affiliations of Mathieu Laplante include Massachusetts Institute of Technology.
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Papers
mTOR Signaling in Growth Control and Disease
Mathieu Laplante,David M. Sabatini +1 more
- 01 Apr 2012
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
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mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
5.7K
mTOR signaling at a glance
TL;DR: The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival.
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Ja Young Kim,Esther Van De Wall,Mathieu Laplante,Anthony Azzara,Maria E. Trujillo,Susanna M. Hofmann,Todd Schraw,Jorge L. Durand,Hua Li,Guangyu Li,Linda A. Jelicks,Mark F. Mehler,David Y. Hui,Yves Deshaies,Gerald I. Shulman,Gary J. Schwartz,Philipp E. Scherer +16 more
TL;DR: It is proposed that adiponectin acts as a peripheral "starvation" signal promoting the storage of triglycerides preferentially in adipose tissue, and reduced triglyceride levels in the liver and muscle convey improved systemic insulin sensitivity.
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson,Mathieu Laplante,Carson C. Thoreen,Yasemin Sancak,Seong A. Kang,W. Michael Kuehl,Nathanael S. Gray,David M. Sabatini +7 more
TL;DR: A novel mTOR-interacting protein whose deregulated overexpression in multiple myeloma cells represents a mechanism for activating PI3K/Akt signaling and promoting cell survival.
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