Mathieu Kurowska
University of Paris
11 Papers
Mathieu Kurowska is an academic researcher from University of Paris. The author has contributed to research in topics: Biology & Degranulation. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Mathieu Kurowska include French Institute of Health and Medical Research & Paris Descartes University.
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Papers
A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.
Fernando E. Sepulveda,Fernando E. Sepulveda,Sophia Maschalidi,Sophia Maschalidi,Christian A. J. Vosshenrich,Alexandrine Garrigue,Alexandrine Garrigue,Mathieu Kurowska,Mathieu Kurowska,Gaël Ménasché,Gaël Ménasché,Alain Fischer,James P. Di Santo,Geneviève de Saint Basile,Geneviève de Saint Basile,Geneviève de Saint Basile +15 more
TL;DR: A crucial role is identified of NK-cell cytotoxicity in limiting HLH-like immunopathology, highlighting the important role of NK cytotoxic activity in immune homeostasis.
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Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
Fernando E. Sepulveda,Fernando E. Sepulveda,Franck Debeurme,Franck Debeurme,Gaël Ménasché,Gaël Ménasché,Mathieu Kurowska,Mathieu Kurowska,Marjorie Côte,Marjorie Côte,Jana Pachlopnik Schmid,Jana Pachlopnik Schmid,Jana Pachlopnik Schmid,Alain Fischer,Alain Fischer,Alain Fischer,Geneviève de Saint Basile,Geneviève de Saint Basile,Geneviève de Saint Basile +18 more
TL;DR: The data indicate that cytotoxic effectors may have other immune-regulatory roles in addition to their role in controlling viral replication in patients with genetic abnormalities expected to result in the complete absence of perforin, Rab27a, or syntaxin-11.
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Actin dynamics regulation by TTC7A/PI4KIIIα axis limits DNA damage and cell death during leukocyte migration
Tania Gajardo,Marie Lô,Mathilde Bernard,Mathilde Bernard,Claire Leveau,Marie-Thérèse El-Daher,Mathieu Kurowska,Gregoire Le Lay,Gregoire Le Lay,Despina Moshous,Despina Moshous,Bénédicte Neven,Bénédicte Neven,Alain Fischer,Alain Fischer,Alain Fischer,Gaël Ménasché,Geneviève de Saint Basile,Geneviève de Saint Basile,Pablo Vargas,Pablo Vargas,Fernando E. Sepulveda,Fernando E. Sepulveda +22 more
TL;DR: In this paper, the authors leverage microfabricated devices to investigate the impact of TTC7A deficiency in leukocyte migration at the single cell level and highlight the role of the protein in the maintenance of the immune homeostasis.
Patent
Methods and pharmaceutical compositions for inhibiting mast cell degranulation
Gaël Ménasché,Ulrich Blank,Luca Danelli,Alain Fischer,Mathieu Kurowska,Isabelle Munoz +5 more
- 07 Apr 2016
TL;DR: In this paper, the authors present methods and pharmaceutical compositions for inhibiting mast cell degranulation in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of an agent capable of inhibiting the formation of the Kinesin-1/Slp3/Rab27b complex.
Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement.
Tania Gajardo,Mathilde Bernard,Marie Lô,Claire Leveau,Marie‐Thérèse El‐Daher,Alexandre Deslys,P. Panikulam,Constantin Menche,Mathieu Kurowska,Gregoire Le Lay,Lucie Barbier,Despina Moshous,Bénédicte Neven,Henner F. Farin,Alain Fischer,Gaël Ménasché,Geneviève de Saint Basile,Pablo Vargas,Fernando E. Sepulveda +18 more
TL;DR: The role of the TTC7A/PI4KIIIα pathway in the control of leukocyte migration and actin dynamics was investigated in this paper . But, the authors did not consider the effect of the PI3K/AKT/RHOA regulatory axis on the actin cytoskeleton dynamics.