Mathew A. Vadas
University of Sydney
166 Papers
3.3K Citations
Mathew A. Vadas is an academic researcher from University of Sydney. The author has contributed to research in topics: Endothelial stem cell & Sphingosine kinase 1. The author has an hindex of 63, co-authored 164 publications. Previous affiliations of Mathew A. Vadas include South Australia Pathology & Centenary Institute.
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Papers
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
3.9K
Recombinant human interleukin 5 is a selective activator of human eosinophil function.
Angel F. Lopez,Colin J. Sanderson,Jennifer R. Gamble,Hugh Campbell,Ian G. Young,Mathew A. Vadas +5 more
TL;DR: Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils, and is thus a prime candidate for the selective eOSinophilia and eos inophil activation seen in disease.
1K
High-Density Lipoproteins Inhibit Cytokine-Induced Expression of Endothelial Cell Adhesion Molecules
TL;DR: Physiological concentrations of HDLs inhibit tumor necrosis factor-alpha or interleukin-1 (IL-1) induction of these leukocyte adhesion molecules in a concentration-dependent manner and have no effect on TNF-alpha-induced expression of ICAM-1 by human foreskin fibroblasts, suggesting that the effect is cell-type restricted.
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Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions
Jennifer R. Gamble,Jenny Drew,Libby Trezise,Anne Underwood,Michelle Parsons,Lisa Kasminkas,John S. Rudge,George D. Yancopoulos,Mathew A. Vadas +8 more
TL;DR: It is shown that angiopoietin-1, a cytokine essential in fetal angiogenesis, not only supports the localization of proteins into junctions between endothelial cells and decreases the phosphorylation of PECAM-1 and vascular endothelial cadherin, but it also strengthens these junctions, as evidenced by a decrease in basal permeability and inhibition of permeability responses to thrombin andascular endothelial growth factor.
548
•Journal Article
A New Method for the Purification of Human Eosinophils and Neutrophils, and a Comparison of the Ability of These Cells to Damage Schistosomula of Schistosoma Mansoni
TL;DR: Centrifugation of human white blood cells over either Ficoll-Hypaque or slightly hypertonic Metrizamide discontinuous gradients reliably produces separate fractions that are enriched for either neutrophilic or eosinophilic granulocytes.
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