Matam Vijay-Kumar
University of Toledo
176 Papers
397 Citations
Matam Vijay-Kumar is an academic researcher from University of Toledo. The author has contributed to research in topics: Gut flora & Colitis. The author has an hindex of 49, co-authored 138 publications. Previous affiliations of Matam Vijay-Kumar include Penn State Cancer Institute & Pennsylvania State University.
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Papers
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Matam Vijay-Kumar,Jesse D. Aitken,Frederic A. Carvalho,Tyler C. Cullender,Simon M. Mwangi,Shanthi Srinivasan,Shanthi V. Sitaraman,Rob Knight,Ruth E. Ley,Andrew T. Gewirtz +9 more
TL;DR: Results support the emerging view that the gut microbiota contributes to metabolic disease and suggest that malfunction of the innate immune system may promote the development of metabolic syndrome.
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Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice
TL;DR: This protocol describes the dextran sulfate sodium (DSS)‐induced colitis model, focusing on details and factors that could affect DSS‐induced pathology.
Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action
TL;DR: The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities as discussed by the authors, and wound healing and detoxifying properties have also received considerable attention.
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Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
Rajbir Singh,Sandeep Chandrashekharappa,Sobha R. Bodduluri,Becca V. Baby,Bindu Hegde,Niranjan G. Kotla,Ankita A. Hiwale,Taslimarif Saiyed,Paresh Patel,Matam Vijay-Kumar,Morgan G. I. Langille,Gavin M. Douglas,Xi Cheng,Eric C. Rouchka,Sabine Waigel,Gerald W. Dryden,Houda Alatassi,Huang-Ge Zhang,Bodduluri Haribabu,Praveen Kumar Vemula,Venkatakrishna R. Jala +20 more
TL;DR: It is shown that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting a potential application for inflammatory bowel diseases.
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Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Frederic A. Carvalho,Frederic A. Carvalho,Frederic A. Carvalho,Omry Koren,Julia K. Goodrich,Malin E. V. Johansson,ILKe Nalbantoglu,Jesse D. Aitken,Yueju Su,Benoit Chassaing,William A. Walters,Antonio Gonzalez,Jose C. Clemente,Tyler C. Cullender,Nicolas Barnich,Arlette Darfeuille-Michaud,Matam Vijay-Kumar,Rob Knight,Rob Knight,Ruth E. Ley,Andrew T. Gewirtz +20 more
TL;DR: An innate immune deficiency can result in unstable gut microbiota associated with low-grade inflammation, and harboring proteobacteria can drive and/or instigate chronic colitis.
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