A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma

The risk of hereditary cutaneous malignant melanoma was evaluated in 401 members of 14 families with an autosomal dominant form of melanoma. We documented 127 primary melanomas in 69 famil...

High Risk of Malignant Melanoma in Melanoma-Prone Families with Dysplastic Nevi

THE incidence of cutaneous malignant melanoma is rising rapidly throughout the world.1 The most current data from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) sy...

Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome.

Objective To determine the frequency of and the histologic and clinical factors associated with melanoma existing in histologic contiguity with a nevus. Design Pathology reports from melanomas collected from January 1, 1993, to December 31, 1997, were retrospectively reviewed. Setting Independent, community-based dermatopathology laboratory. Patients A total of 1606 patients with a histologic diagnosis of melanoma. Intervention None. Main Outcome Measures Differences in histologic (subtype, Breslow thickness, and Clark level) and clinical (age, sex, and anatomic location) features between melanomas that are associated and unassociated with a nevus. Results Twenty-six percent of the melanomas reviewed were histologically associated with nevi (dysplastic nevi, 43.0%; and other nevi, 57.0%). Factors that were significantly associated with an increased likelihood of a melanoma being histologically contiguous with a nevus included younger age, superficial spreading subtype, truncal location, Breslow thickness, and Clark level. However, after multivariate analysis, only younger age (odds ratio, 1.27; 95% confidence interval, 1.19-1.37), superficial spreading subtype (odds ratio, 2.96; 95% confidence interval, 2.17-4.02), and truncal location (odds ratio, 3.26; 95% confidence interval, 2.55-4.19) remained significant. Conclusions Most melanomas were not histologically contiguous with a nevus. Younger age, superficial spreading subtype, and truncal location are independent significant predicators of a melanoma being histologically associated with a nevus.

Cutaneous melanomas associated with nevi.

A study of 207 consecutive white patients older than 18 years of age with nonfamilial nodular and superficial spreading melanoma and 295 controls was conducted in southeast France. Controls were recruited in a public health center. They were matched for sex and age to the overall population older than 18 years of age according to the last census. Melanocytic nevi were counted over the entire body, and data on sun exposure and skin type were collected. A multiple logistic model was used to determine the variables best predicting the risk of melanoma. In order of entry into the model, these variables were number of nevi from 5 to less than 10 mm (N5/10), outdoor leisure per year, frequency of sunburn in the last years, depth of suntan, number of nevi less than 5 mm in diameter (N1/5), age, social level, and hair color. Nevi counts were shown to be indispensable to the construction of a good predictive model for nonfamilial melanoma. After adjustment, estimated relative risks for nonfamilial melanoma rose with increasing number of N1/5, N5/10, and clinically atypical nevi (CAN) on the whole body. Compared with baseline groups the presence of more than 120 N1/5 was associated with a RR of 19.6, the presence of at least five N5/10 with a RR of 10, and the presence of more than one CAN with a RR of 2.77. The number of nevi on the buttocks seemed to be a strong risk factor of melanoma and may provide a simple technique for mass screening. The association between CAN and nonfamilial melanoma could be explained largely by the association between this tumor and the number of large nevi (greater than or equal to 5 mm). It is suggested that when using number of nevi as risk markers, their size might be more important than the other features of clinical atypia. Phenotypic traits and sun exposure, on the one hand, and number of nevi, on the other, seem to be independent risk factors. On the basis of nevus count alone, high-risk subgroups can be identified, which represent only a small part of the overall population older than 18 years of age and from which a large proportion nonfamilial melanoma would theoretically derive.

https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/1097-0142%2819900715%2966%3A2%3C387%3A%3AAID-CNCR2820660232%3E3.0.CO%3B2-J

Count of benign melanocytic nevi as a major indicator of risk for nonfamilial nodular and superficial spreading melanoma.

11 Acquired melanocytic nevi and melanoma. The dysplastic nevus syndrome

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11 Acquired melanocytic nevi and melanoma. The dysplastic nevus syndrome