Massimo Tempestilli
National Institutes of Health
47 Papers
219 Citations
Massimo Tempestilli is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Ritonavir. The author has an hindex of 16, co-authored 41 publications.
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Papers
UPLC–MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients
Stefania Notari,Massimo Tempestilli,Gabriele Fabbri,Raffaella Libertone,Andrea Antinori,Adriana Ammassari,Chiara Agrati +6 more
TL;DR: An UPLC-MS/MS method allowing the simultaneous quantification of sofosbuvir, GS-331007 and daclatasvir in plasma samples was developed and validated and was sensitive, specific, robust, and time-saving.
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Transplacental Transfer of Antiretroviral Drugs and Newborn Birth Weight in HIV-Infected Pregnant Women
Jelena Ivanovic,Emanuele Nicastri,Maurizio M. Anceschi,Paolo Ascenzi,Fabrizio Signore,Giuseppe Pisani,Cristina Vallone,Elisabetta Mattia,Stefania Notari,Massimo Tempestilli,Leopoldo Paolo Pucillo,Pasquale Narciso +11 more
TL;DR: Data indicated a pharmacological rationale to the association between birth weight and highly active antiretroviral therapy during pregnancy and the clinical assessment of the newborn are indicated.
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Simultaneous determination of maraviroc and raltegravir in human plasma by HPLC-UV.
Stefania Notari,Chiara Tommasi,Emanuele Nicastri,Rita Bellagamba,Massimo Tempestilli,Leopoldo Paolo Pucillo,Pasquale Narciso,Paolo Ascenzi +7 more
TL;DR: The HPLC–UV method reported here has been validated and is currently applied to monitor plasma levels of maraviroc and raltegravir in HIV‐infected patients.
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Multicompartment vectors as novel drug delivery systems: selective activation of Tγδ lymphocytes after zoledronic acid delivery.
Chiara Agrati,Carlotta Marianecci,Simona Sennato,Maria Carafa,Veronica Bordoni,Eleonora Cimini,Massimo Tempestilli,Leopoldo Paolo Pucillo,Federica Turchi,Federico Martini,Giorgio Borioni,Federico Bordi +11 more
TL;DR: The effectiveness of aminobisphosphonate zoledronate is demonstrated to enhance the recruitment of Tγδ lymphocytes by macrophage by 2 orders of magnitude, suggesting a new therapeutic strategy for addressing pathologies featuring chronically infected macrophages.
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Accumulation of dysfunctional effector CD8+ T cells in the liver of patients with chronic HCV infection.
Carla Nisii,Massimo Tempestilli,Chiara Agrati,Fabrizio Poccia,Guido Tocci,Maria Antonella Longo,Gianpiero D'Offizi,Roberto Tersigni,Oreste Lo Iacono,Giorgio Antonucci,Alessandra Oliva +10 more
TL;DR: Intrahepatic CD8+T cells of HCV-infected patients, despite their phenotype of pre-terminally and terminally differentiated effectors, are poorly responsive to T cell receptor (TCR)-mediated stimulation compared with those obtained from uninfected subjects.
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