Massimo Signore
King's College London
11 Papers
146 Citations
Massimo Signore is an academic researcher from King's College London. The author has contributed to research in topics: Neuroectoderm & Hindbrain. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Massimo Signore include International Institute of Minnesota.
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Papers
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.
Eduardo Puelles,Dario Acampora,Emmanuel Lacroix,Massimo Signore,Alessandro Annino,Francesca Tuorto,Stefania Filosa,Giorgio Corte,Wolfgang Wurst,Siew-Lan Ang,Antonio Simeone +10 more
TL;DR: The data indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression and it is proposed that this mechanism may provide both A–P and D–V positional information to neuronal precursors located within the midbrain.
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Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain–Hindbrain Organizer
Claude Brodski,Daniela M. Vogt Weisenhorn,Massimo Signore,Inge Sillaber,Matthias Oesterheld,Vania Broccoli,Dario Acampora,Antonio Simeone,Wolfgang Wurst +8 more
TL;DR: In this paper, the authors investigated the role of the position of the midbrain during embryogenesis in the development of the serotonergic and dopamine neurons and found that the location of the MHO determines the location and size of midbrain and hindbrain cell populations in vivo.
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Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
Gabriella Minchiotti,Silvia Parisi,Giovanna L. Liguori,Massimo Signore,Gabriella Lania,Eileen D. Adamson,C. T. Lago,M. Graziella Persico +7 more
TL;DR: It is suggested that presentation of Cripto on the cell surface via a GPI-linkage is important in determining the spatial specificity of cell-cell interactions that play a critical role in the early patterning of the embryo.
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Otx1 null mutant mice show partial segregation of sensory epithelia comparable to lamprey ears.
TL;DR: It is proposed that Otx1 is not directly involved in sensory hair cell formation of the horizontal canal but affects the segregation of the vertical canal crista from the utricle, which affects constriction of the two main foramina in the ear, but not their initial formation.
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Otx genes in the development and evolution of the vertebrate brain
Pietro Pilo Boyl,Massimo Signore,Alessandro Annino,Juan Pedro Martinez Barbera,Dario Acampora,Antonio Simeone +5 more
TL;DR: A crucial role is highlighted for the Otx genes in specification, regionalization and terminal differentiation of rostral central nervous system and lead to hypothesize that modification of their regulatory control may have influenced the morphogenesis and evolution of the brain.
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