Massimo Breda
Pharmacia
7 Papers
51 Citations
Massimo Breda is an academic researcher from Pharmacia. The author has contributed to research in topics: Bioanalysis & Mass spectrometry. The author has an hindex of 4, co-authored 4 publications.
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Papers
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.
Nadja E. Schoemaker,C. van Kesteren,Hilde Rosing,Sindy Jansen,M. Swart,Jan Lieverst,D Fraier,Massimo Breda,C Pellizzoni,R Spinelli,M Grazia Porro,Jos H. Beijnen,Jos H. Beijnen,Jan H.M. Schellens,Jan H.M. Schellens,W.W. ten Bokkel Huinink +15 more
TL;DR: The pharmacokinetics of camptothecin were dramatically changed, showing controlled prolonged exposure of camPTothecin, and the dose-limiting toxicities were found dose limiting.
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Ion-suppression effects in liquid chromatography-tandem mass spectrometry due to a formulation agent, a case study in drug discovery bioanalysis.
TL;DR: Strong ion-suppression from a polysorbate co-solvent, which, if undetected, would have given highly erroneous pharmacokinetic results and possibly could have led to the inappropriate elimination of a promising drug candidate is observed.
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Hydrophilic interaction liquid chromatography-APCI-mass spectrometry determination of 5-fluorouracil in plasma and tissues.
TL;DR: The HILIC system overcomes problems reported in obtaining satisfactory retention of 5-FU with other types of HPLC systems and the suitability and robustness of the method for in vivo samples were confirmed by analysis of mouse plasma, muscle and tumour from animals dosed with5-FU.
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Assessment of normal and tumor tissue uptake of MAG-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma
Nenad Sarapa,Margaret R. Britto,William Speed,MariaGabriella Jannuzzo,Massimo Breda,C. A. James,MariaGrazia Porro,M. Rocchetti,Alkvin Wanders,Haile Mahteme,Peter Nygren +10 more
TL;DR: Delivery of CPT to the target tumor tissue is achievable by means of the MAG-CPT polymer-bound delivery system, with the equilibrium between plasma and tumor tissue concentrations of released CPT being established within 24 h after dosing.
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Validation of an LC-MS/MS method for the quantification IOA-289 in human plasma and its application in a first-in-human clinical trial.
M Mameli,Jacques Franchi,Giulia Calusi,Marcel A. Deken,Zoë Johnson,Lars A. van der Veen,M. Lahn,A. Vezzelli,Roberto Cardin,Alessandro Greco,Massimo Breda +10 more
TL;DR: A method for quantification of IOA-289 in human plasma was developed using a stable isotope labeled compound ([13C4]IOA-289) as internal standard as mentioned in this paper .
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