Massimiliano Mazzone
Katholieke Universiteit Leuven
196 Papers
383 Citations
Massimiliano Mazzone is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 53, co-authored 171 publications. Previous affiliations of Massimiliano Mazzone include Catholic University of Leuven & The Catholic University of America.
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Papers
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.
Selma Pennacchietti,Paolo Michieli,Maria Galluzzo,Massimiliano Mazzone,Silvia Giordano,Paolo M. Comoglio +5 more
TL;DR: It is shown that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer.
1.3K
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Pu-Ste Liu,Haiping Wang,Xiaoyun Li,Tung Chao,Tony Teav,Stefan Christen,Stefan Christen,Giusy Di Conza,Wan-Chen Cheng,Chih Hung Chou,Magdalena Vavakova,Charlotte Muret,Koen Debackere,Koen Debackere,Massimiliano Mazzone,Massimiliano Mazzone,Hsien Da Huang,Sarah-Maria Fendt,Sarah-Maria Fendt,Julijana Ivanisevic,Ping-Chih Ho +20 more
TL;DR: New mechanistic regulations by which glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming are revealed.
885
Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels
Christian Fischer,Bart Jonckx,Massimiliano Mazzone,Serena Zacchigna,Sonja Loges,Lucia Pattarini,Emmanuel Chorianopoulos,Laurens Liesenborghs,Marta Koch,Maria De Mol,Monica Autiero,Sabine Wyns,Stéphane Plaisance,Lieve Moons,Nico van Rooijen,Mauro Giacca,Jean-Marie Stassen,Mieke Dewerchin,Desire Collen,Peter Carmeliet +19 more
TL;DR: The efficacy and safety ofalphaPlGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alphaPlGF may constitute a novel approach for cancer treatment.
856
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone,Massimiliano Mazzone,Daniela Dettori,Daniela Dettori,Daniela Dettori,Rodrigo Leite de Oliveira,Rodrigo Leite de Oliveira,Sonja Loges,Sonja Loges,Thomas Schmidt,Thomas Schmidt,Bart Jonckx,Bart Jonckx,Ya Min Tian,Anthony A. Lanahan,Patrick J. Pollard,Carmen Ruiz de Almodovar,Carmen Ruiz de Almodovar,Frederik De Smet,Frederik De Smet,Stefan Vinckier,Stefan Vinckier,Julián Aragonés,Julián Aragonés,Koen Debackere,Koen Debackere,Aernout Luttun,Sabine Wyns,Sabine Wyns,Bénédicte F. Jordan,Alberto Pisacane,Bernard Gallez,Maria Grazia Lampugnani,Elisabetta Dejana,Michael Simons,Peter J. Ratcliffe,Patrick H. Maxwell,Peter Carmeliet,Peter Carmeliet +38 more
TL;DR: In this paper, the role of endothelial PHD2 in vessel shaping by implanting tumors in mice was investigated. But, the authors did not find that PHD deficiency did not affect vessel density or lumen size.
837
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Charlotte Rolny,Massimiliano Mazzone,Sonia Tugues,Damya Laoui,Irja Johansson,Cathy Coulon,Mario Leonardo Squadrito,Inmaculada Segura,Xiujuan Li,Ellen Knevels,Sandra Costa,Stefan Vinckier,Tom Dresselaer,Peter Åkerud,Maria De Mol,Henriikka Salomäki,Mia Phillipson,Sabine Wyns,Erik G. Larsson,Ian Buysschaert,Johan Botling,Uwe Himmelreich,Jo A. Van Ginderachter,Michele De Palma,Mieke Dewerchin,Lena Claesson-Welsh,Peter Carmeliet +26 more
TL;DR: It is reported that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy, and offers therapeutic opportunities for anticancer and antiangiogenic treatment.
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