Masashi Yanagisawa
University of Tsukuba
563 Papers
8.6K Citations
Masashi Yanagisawa is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin receptor & Endothelin 1. The author has an hindex of 130, co-authored 524 publications. Previous affiliations of Masashi Yanagisawa include Case Western Reserve University & Kyoto University.
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Papers
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA
Takeshi Sakurai,Masashi Yanagisawa,Akihiro Inoue,Una S. Ryan,Sadao Kimura,Youji Mitsui,Katsutoshi Goto,Tomoh Masaki +7 more
TL;DR: The cloning of a full-length cDNA encoding rat preproendothelin-1 suggests that ET-1 may play roles as a local mediator in multiple organs both within and outside the cardiovascular system in the rat.
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Endothelin: 30 Years From Discovery to Therapy.
TL;DR: The role of endothelin in cardiovascular diseases such as arterial hypertension, preecclampsia, coronary atherosclerosis, myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) caused by spontaneous coronary artery dissection, Takotsubo syndrome, and heart failure is discussed.
240
Structure-activity relationships of endothelin: importance of the C-terminal moiety.
Sadao Kimura,Yoshitoshi Kasuya,Tatsuya Sawamura,Osamu Shinmi,Yoshiki Sugita,Masashi Yanagisawa,Katsutoshi Goto,Tomoh Masaki +7 more
TL;DR: Results indicate that the C-terminal Trp of ET is especially important for the potent and extremely long-lasting vasoconstrictor activity characteristic to ET.
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Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight.
TL;DR: Investigation of the effects of chronic administration of orexin in rats by continuous intracerebroventricular administration by means of an osmotic minipump showed that continuous administration of Orexin-A could not overcome the regulation of energy homeostasis and body weight, however, orexIn-A might be implicated in short-term, immediate regulation of feeding behavior.
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Binding and receptor down-regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells.
TL;DR: The data suggest that tight association of ET with its receptor is due to a strong interaction of its hydrophobic domain with the membrane lipids and/or its internalization within cells and that down‐regulation of ET receptor is functionally linked to decreased ET‐induced [Ca2+]i response.
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