Masanori Baba
Kagoshima University
26 Papers
331 Citations
Masanori Baba is an academic researcher from Kagoshima University. The author has contributed to research in topics: Bicyclic molecule & Cyclic compound. The author has an hindex of 12, co-authored 26 publications. Previous affiliations of Masanori Baba include Takeda Pharmaceutical Company & Showa University.
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Papers
Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety.
Masaki Seto,Naoki Miyamoto,Katsuji Aikawa,Yoshio Aramaki,Naoyuki Kanzaki,Yuji Iizawa,Masanori Baba,Mitsuru Shiraishi +7 more
TL;DR: 1-propyl- or 1-isobutyl-1-benzazepine derivatives containing a sulfoxide moiety have been designed, synthesized, and evaluated for their biological activities and found that S-sulfoxide compounds were more active than R-isomers.
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Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.
Kazuhiro Haraguchi,Shingo Takeda,Hiromichi Tanaka,Takao Nitanda,Masanori Baba,Ginger E. Dutschman,Yung-Chi Cheng +6 more
TL;DR: The 4'-ethynyl analogue (15) was found to be more potent and less toxic than the parent compound stavudine.
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CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives
Shinichi Imamura,Youichi Nishikawa,Takashi Ichikawa,Taeko Hattori,Yoshihiro Matsushita,Shohei Hashiguchi,Naoyuki Kanzaki,Yuji Iizawa,Masanori Baba,Yoshihiro Sugihara +9 more
TL;DR: The selected compound 11f showed excellent antiviral activity against CCR5-using HIV-1 replication in human peripheral blood mononuclear cells and an acceptable pharmacokinetic profile in dogs.
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Patent
Cyclic amine compounds as ccr5 antagonists
Imamura Shinichi,Hashiguchi Shohei,Hattori Taeko,Osamu Nishimura,Kanzaki Naoyuki,Masanori Baba,Sugihara Yoshihiro +6 more
- 29 Sep 2000
TL;DR: In this paper, a compound of formula (I) is defined as a mixture of two compounds, where the first compound is a hydrogen atom, the second is a cyclic hydrocarbon group, and the third is a heterocyclic group.
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CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives
Shinichi Imamura,Yuji Ishihara,Taeko Hattori,Osamu Kurasawa,Yoshihiro Matsushita,Yoshihiro Sugihara,Naoyuki Kanzaki,Yuji Iizawa,Masanori Baba,Shohei Hashiguchi +9 more
TL;DR: A novel lead compound, N-(3-[4-(4-fluorobenzoyl)piperidin-1-yl]propyl)-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide (1), was identified as a CCR5 antagonist by high-throughput screening using [(125)I]RANTES and C CR5-expressing CHO cells.
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