Masahiko Hibi
Nagoya University
147 Papers
1.5K Citations
Masahiko Hibi is an academic researcher from Nagoya University. The author has contributed to research in topics: Zebrafish & Biology. The author has an hindex of 66, co-authored 141 publications. Previous affiliations of Masahiko Hibi include University of California, San Diego & University of Massachusetts Medical School.
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Papers
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Benoit Dérijard,Benoit Dérijard,Masahiko Hibi,I-Huan Wu,I-Huan Wu,Tamera Barrett,Bing Su,Tiliang Deng,Michael Karin,Roger J. Davis,Roger J. Davis +10 more
TL;DR: JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation and its properties indicate that JNK1 activation may play an important role in tumor promotion.
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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
TL;DR: This work has identified a serine/threonine kinase whose activity is stimulated by the same signals that stimulate the amino-terminal phosphorylation of c-Jun, and suggests a mechanism through which protein kinase cascades can specifically modulate the activity of distinct nuclear targets.
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Tetsuya Taga,Masahiko Hibi,Y. Hirata,Katsuhiko Yamasaki,Kiyoshi Yasukawa,Tadashi Matsuda,Toshio Hirano,Tadamitsu Kishimoto +7 more
TL;DR: It is reported that an 80 kd single polypeptide chain (IL-6-R) is involved in IL-6 binding and that IL- 6 triggers the association of this receptor with a non-ligand-binding membrane glycoprotein, gp130, extracellularly and can provide the IL-7 signal.
1.5K
Molecular cloning and expression of an IL-6 signal transducer, gp130
Masahiko Hibi,Masaaki Murakami,Mikiyoshi Saito,Toshio Hirano,Tetsuya Taga,Tadamitsu Kishimoto +5 more
TL;DR: A cloned gp130 could associate with a complex of IL-6 and solubleIL-6-R and transduce the growth signal when expressed in a murine IL-3-dependent cell line and confirmed that a gp130 is involved in the formation of high affinity IL- 6 binding sites.
1.3K
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
TL;DR: Since the IL-6/gp130/STAT3 signaling pathway is involved in both B cell growth and differentiation into plasma cells it is likely to play a central role in the generation of plasma cell neoplasias.
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