Masaaki Kimura
Taisho Pharmaceutical Co.
26 Papers
258 Citations
Masaaki Kimura is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Toxicity & Genotoxicity. The author has an hindex of 10, co-authored 26 publications.
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Papers
Behavioral, electroencephalographic and histopathological studies on mongolian gerbils with occluded common carotid arteries
TL;DR: It is suggested that the hippocampal damage, especially abnormalities in the CA1 neurons, evidenced by histopathological and electroencephalographic results, may be related to deficits in memory following bilateral common carotid arteries occlusion.
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Spontaneous degenerative polyarthritis in male New Zealand black/KN mice.
Kunie Nakamura,Sadao Kashiwazaki,Kenji Takagishi,Yukio Tsukamoto,Yasuo Morohoshi,Takeshi Nakano,Masaaki Kimura +6 more
TL;DR: This animal model of arthritis will be extremely useful for analyzing not only the pathogenesis of rheumatoid arthritis, but also new strategies for its treatment, since NZB/KN mice, unlike MRL/lpr mice, do not develop severe lupus nephritis or lymph-adenopathy, and therefore have a longer survival period.
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Increased activity of vascular ACE related to atherosclerotic lesions in hyperlipidemic rabbits.
TL;DR: It is conceivable that increased ACE in the vascular walls is involved in hyperlipidemia-induced atherogenesis, presumably through production of growth or stimulating factor(s) contributing to plaque formation.
31
Mutations induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lacZ and cII genes of Muta™ Mouse
TL;DR: Observations show that NNK predominantly induces DNA adducts leading to A:T to T:A and/or A-T to C:G mutations in the transgene.
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Genotoxicity of o-aminoazotoluene (AAT) determined by the Ames test, the in vitro chromosomal aberration test, and the transgenic mouse gene mutation assay
TL;DR: The transgenic mouse mutation assay proved to be useful for concurrent assessment of in vivo mutagenicity in multiple organs and to supplement the standard in vivo genotoxicity tests, such as the micronucleus assay which is limited to bone marrow as the only target organ.
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