Mary-Louise Risher
Duke University
21 Papers
18 Citations
Mary-Louise Risher is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Hippocampal formation. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Mary-Louise Risher include Veterans Health Administration & Marshall University.
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Papers
Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.
Mary-Louise Risher,Hannah G. Sexton,W. Christopher Risher,Wilkie A. Wilson,Rebekah L. Fleming,Roger D. Madison,Scott D. Moore,Cagla Eroglu,H. Scott Swartzwelder +8 more
TL;DR: Repeated EtOH exposure during adolescence results in long-term changes in specific astrocyte signaling proteins and their neuronal synaptogenic receptor, and consequently contribute to the enduring maladaptive structural and functional abnormalities previously observed in the hippocampus after AIE.
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Binge‐Pattern Ethanol Exposure During Adolescence, but Not Adulthood, Causes Persistent Changes in GABAA Receptor‐Mediated Tonic Inhibition in Dentate Granule Cells
Rebekah L. Fleming,Rebekah L. Fleming,Qiang Li,Qiang Li,Mary-Louise Risher,Mary-Louise Risher,Hannah G. Sexton,Scott D. Moore,Scott D. Moore,Wilkie A. Wilson,Wilkie A. Wilson,Shawn K. Acheson,Shawn K. Acheson,H. Scott Swartzwelder,H. Scott Swartzwelder +14 more
TL;DR: These findings underscore the recent report that CIE during adolescence results in enduring alterations in tonic current and its acute EtOH sensitivity and establish that adolescence is a developmental period during which the hippocampal formation is distinctively vulnerable to long-term alteration by chronic EtOH exposure.
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Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse
Christopher D. Walker,W. Christopher Risher,Mary-Louise Risher,Mary-Louise Risher,Mary-Louise Risher +4 more
TL;DR: Several key astrocyte signaling factors (thrombospondins, netrins, apolipoproteins, neuregulins, bone morphogenetic proteins, and neuroligins) in the maintenance and regulation of synapse formation are discussed.
Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus
Samuel W. Centanni,Tara Teppen,Tara Teppen,Mary-Louise Risher,Mary-Louise Risher,Rebekah L. Fleming,Rebekah L. Fleming,Julia L. Moss,Shawn K. Acheson,Shawn K. Acheson,Patrick J. Mulholland,Subhash C. Pandey,Subhash C. Pandey,L. Judson Chandler,H. S. Swartzwelder,H. S. Swartzwelder +15 more
TL;DR: In contrast to the effects of AIE, chronic intermittent ethanol exposure during adulthood had no effect on expression of any of the GABAA R subunits examined, and underscores the emerging view of adolescence as a time of distinctive vulnerability to the enduring effects of repeated EtOH exposure.
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Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.
Anze Testen,Maryam Ali,Hannah G. Sexton,Sierra Hodges,Kira Dubester,Kathryn J. Reissner,H. Scott Swartzwelder,Mary-Louise Risher +7 more
TL;DR: Novel insight is provided into region-specific astrocyte-synapse interactions in late CNS development and into adulthood, thus raising implications for the mechanism of post-adolescent development of the mPFC.
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