Marty G. Yang
Harvard University
11 Papers
37 Citations
Marty G. Yang is an academic researcher from Harvard University. The author has contributed to research in topics: Regulation of gene expression & Transcription (biology). The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Marty G. Yang include Duke University.
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Papers
Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum
Christopher L. Frank,Fang Liu,Ranjula Wijayatunge,Lingyun Song,Matthew T. Biegler,Marty G. Yang,Christopher M. Vockley,Alexias Safi,Charles A. Gersbach,Gregory E. Crawford,Anne E. West +10 more
TL;DR: It is found that Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns necessary for neuronal differentiation and function.
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Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.
Liang-Fu Chen,Yen Ting Lin,David A. Gallegos,Mariah F. Hazlett,Mariana Gómez-Schiavon,Marty G. Yang,Breanna Kalmeta,Allen S. Zhou,Liad Holtzman,Charles A. Gersbach,Jörg Grandl,Nicolas E. Buchler,Nicolas E. Buchler,Anne E. West +13 more
TL;DR: Activity-inducible histone acetylation tunes the transcriptional dynamics of experience-regulated genes to affect selective changes in neuronal gene expression and cellular function.
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Evolution of Osteocrin as an activity-regulated factor in the primate brain
Bulent Ataman,Gabriella L. Boulting,David A. Harmin,Marty G. Yang,Mollie Baker-Salisbury,Ee Lynn Yap,Athar N. Malik,Kevin Mei,Alex A. Rubin,Ivo Spiegel,Ershela Durresi,Nikhil Sharma,Linda Hu,Mihovil Pletikos,Eric C. Griffith,Jennifer N. Partlow,Christine Stevens,Mazhar Adli,Maria H. Chahrour,Nenad Sestan,Christopher A. Walsh,Vladimir K. Berezovskii,Margaret S. Livingstone,Michael E. Greenberg +23 more
TL;DR: Greenberg et al. as mentioned in this paper found that OSTN has been repurposed in primates through the evolutionary acquisition of DNA regulatory elements that bind the activity-regulated transcription factor MEF2.
MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes
Lisa D. Boxer,William Renthal,Alexander W. Greben,Tess Whitwam,Andrew Silberfeld,Hume Stroud,Emmy Li,Marty G. Yang,Benyam Kinde,Eric C. Griffith,Boyan B. Bonev,Michael E. Greenberg +11 more
TL;DR: It is demonstrated here that MeCP2 represses nascent RNA transcription of highly methylated long genes in the brain through its interaction with the NCoR co-repressor complex, and suggests a new model of Me CP2 function in which MeCP 2 binds broadly across highlymethylated regions of DNA, but acts at transcription start sites to attenuate transcriptional initiation.
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Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease
Timothy J. Cherry,Timothy J. Cherry,Marty G. Yang,David A. Harmin,Peter Tao,Andrew E. Timms,Miriam Bauwens,Rando Allikmets,Evan M Jones,Rui Chen,Elfride De Baere,Michael E. Greenberg +11 more
TL;DR: This comprehensive analysis of tissue-specific regulatory elements, transcription factor binding, and gene expression programs in three regions of the human visual system reveals features of regulatory element evolution that shape tissue- specific gene expression Programs and defines regulatory elements with the potential to contribute to Mendelian and complex disorders of human vision.
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