Martine C. Lans
4 Papers
2 Citations
Martine C. Lans is an academic researcher. The author has contributed to research in topics: Transthyretin & Chemistry. The author has an hindex of 3, co-authored 4 publications.
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Papers
Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin
Martine C. Lans,E. Klasson-Wehler,Marcel Willemsen,Elise Meussen,Stephen Safe,Abraham Brouwer +5 more
TL;DR: A profound similarity in structural requirements for TTR binding between hydroxy-PCB, -PCDD and -PCDF metabolites and the physiological ligand, T4 is found, e.g. halogen substitution adjacent to the para hydroxy group, while planarity does not seem to influence the ligand-binding potency.
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Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs.
TL;DR: Results indicate a marked difference in T4 binding to thyroxine-binding globulin or transthyretin, and thus may cause different effects in rodents and man.
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Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.
TL;DR: X-ray crystallography studies performed on the recombinant TTR Met 119 variant revealed structural alterations mainly at the level of residue Leu 110 allowing a closer contact between the hormone and the mutant protein, consistent with the observed T4 binding results.
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