Martina U. Muckenthaler
Heidelberg University
250 Papers
1.9K Citations
Martina U. Muckenthaler is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hepcidin & Medicine. The author has an hindex of 63, co-authored 219 publications. Previous affiliations of Martina U. Muckenthaler include University of Pennsylvania & Boston Children's Hospital.
Chat about Author
Papers
High Circulating Iron Levels Are a Risk Factor for Cardiovascular Disease: Clinical Implications for Iron-Overload Conditions
Francesca Vinchi,Francesca Vinchi,Andreas Simmelbauer,Andreas Simmelbauer,Milene Costa da Silva,Milene Costa da Silva,Sandro Altamura,Sandro Altamura,Bruno Galy,Matthias W. Hentze,Matthias W. Hentze,Martina U. Muckenthaler,Martina U. Muckenthaler +12 more
TL;DR: With increasing age, high circulating iron levels strongly enhance the severity of the atherosclerotic phenotype, indicating that systemic iron overload is a risk factor for atherosclerosis progression and predisposes to cardiovascular disease.
1
Activating Mutation of Heme Oxygenase (HO)-1: A Novel Disease Entity Characterized by Microcytic, Hemolytic Anemia, a Defect of Bilirubin Synthesis and Hereditary Hemophagocytic Lymphohistiocytosis.
Johann Greil,Mavi Verga-Falzacappa,Hirokazu Tsukahara,Wolfgang Behnisch,Hermann Heimpel,Marion Schneider,Gritta Janka,Maren Claus,Martina U. Muckenthaler,Andreas E. Kulozik +9 more
TL;DR: A novel form of hereditary HLH that is related to and possibly caused by a homozygous missense mutation (G139V) of the active centre of heme oxygenase-1 (HO-1) is identified which results in a defect of hemoglobin degradation, bilirubin synthesis and in excessive oxidative stress and inflammation.
1
NOTCH1 Activation Neutralizes the Unfavorable Prognostic Effect of PTEN Mutations in BFM-Treated Children with T-ALL
Obul Reddy Bandapalli,Corinne Kox,Martin Zimmermann,Martin Stanulla,Martin Schrappe,Wolf-Dieter Ludwig,Rolf Koehler,Martina U. Muckenthaler,Andreas E. Kulozik +8 more
TL;DR: The clinical interaction of PTEN and NOTCH1 mutations in a cohort of 301 children with T-ALL who were treated on ALL-BFM protocols and the analysis of MRD responses on day 78 and of long term survival showed that the favorable effect ofnotCH1 neutralizes the unfavorable effect ofPTEN.
1