Martina U. Muckenthaler
Heidelberg University
250 Papers
1.9K Citations
Martina U. Muckenthaler is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hepcidin & Medicine. The author has an hindex of 63, co-authored 219 publications. Previous affiliations of Martina U. Muckenthaler include University of Pennsylvania & Boston Children's Hospital.
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Papers
HFE and ALK3 act in the same signaling pathway
Lara Traeger,J. Schnittker,D.Y. Dogan,D. Oguama,Tanja Kuhlmann,Martina U. Muckenthaler,Jan Krijt,Eugen I. Urzica,Andrea U. Steinbicker +8 more
TL;DR: Evidence is provided by genetic means that HFE exclusively uses the BMP type I receptor ALK3 to induce hepcidin expression and HFE protein expression is induced by iron overload, which further emphasizes the iron sensing function of HFE.
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Das hereditäre Hyperferritinämie-Katarakt-Syndrom – die erste Familie in Deutschland
Gunda Millonig,M. P. Holzer,Tolle G,Auffarth Gu,Martina U. Muckenthaler,Helmut-Karl Seitz,Sebastian Mueller +6 more
TL;DR: In gastroenterological practice, HHCS should be added as a differential diagnosis of hyperferritinemia in Germany so that patients with HHCS can be spared from invasive diagnostics such as liver biopsy.
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Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.
Sajib Chakraborty,Geoffroy Andrieux,Philipp Kastl,Lorenz Adlung,Sandro Altamura,Martin E. Boehm,Luisa E. Schwarzmüller,Yomn Abdullah,Marie-Christine Wagner,Barbara Helm,Hermann Josef Gröne,Wolf D. Lehmann,Melanie Boerries,Hauke Busch,Martina U. Muckenthaler,Marcel Schilling,Ursula Klingmüller +16 more
TL;DR: In the absence of the Epo receptor (EpoR) in embryos, they observed a lack of hemoglobin in CFU-E cells and massive iron overload of the fetal liver pointing to a miscommunication between liver and placenta as discussed by the authors .
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Hypoferremia Predicts Hospitalization and Oxygen Demand in COVID-19 Patients
TL;DR: Measurement of serum iron can help predicting the severity of COVID-19, and the differences in serum iron availability observed between the low and high oxygen demand group suggest that disturbed iron metabolism likely plays a causal role in the pathophysiology leading to lung injury.
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Iron-dependent BMP6 Regulation in Liver Sinusoidal Endothelial Cells Is Instructed by Hepatocyte-derived Secretory Signals
Silvia Colucci,Sandro Altamura,Oriana Marques,Katja Müdder,Anand R. Agarvas,Matthias W. Hentze,Martina U. Muckenthaler +6 more
TL;DR: Findings suggest that the iron-de- pendent BMP6 regulation in LSECs is not cell autonomous, and the treatment of mice with ferritin 17 may Bmp6 expression levels in L SECs indirectly.
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