Martina U. Muckenthaler
Heidelberg University
250 Papers
1.9K Citations
Martina U. Muckenthaler is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hepcidin & Medicine. The author has an hindex of 63, co-authored 219 publications. Previous affiliations of Martina U. Muckenthaler include University of Pennsylvania & Boston Children's Hospital.
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Papers
Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin
Ana Rita da Silva,Ana Rita da Silva,Joana Neves,Joana Neves,Joana Neves,Katarzyna Mleczko-Sanecka,Katarzyna Mleczko-Sanecka,Amol Tandon,Sven W. Sauer,Matthias W. Hentze,Martina U. Muckenthaler,Martina U. Muckenthaler +11 more
TL;DR: It is demonstrated that the inhibition of citrate-consuming enzymes increases hepcidin mRNA expression in primary murine hepatocytes and that the hePCidin response to citrate involves the SMAD signaling pathway.
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Hypoferremia predicts hospitalization and oxygen demand in COVID-19 patients
TL;DR: Measurement of serum iron can help predicting the severity of COVID-19, and the differences in serum iron availability observed between the low and high oxygen demand group suggest that disturbed iron metabolism likely plays a causal role in the pathophysiology leading to lung injury.
Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes
Ruiyue Qiu,Kristina Alikhanyan,Nadine Volk,Oriana Marques,Christina Mertens,Anand R. Agarvas,Sanjana Singh,Rainer Pepperkok,Sandro Altamura,Martina U. Muckenthaler +9 more
TL;DR: In this article , the authors investigated how the control of iron metabolism in hepatocytes is affected by type 2 diabetes mellitus (T2DM), and established cellular models of insulin resistance by treatment with palmitate and insulin.
7
Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis
Christoph Metzendorf,Anja Zeigerer,Sarah Seifert,Richard Sparla,Richard Sparla,Bahar Najafi,François Canonne-Hergaux,Marino Zerial,Martina U. Muckenthaler,Martina U. Muckenthaler +9 more
TL;DR: The small GTPase Rab5 was specifically depleted in the mouse liver, causing a transient loss of the entire endo-lysosomal system, leading to a fast reduction of hepatic iron levels, which was preceded by an increased abundance of the iron exporter ferroportin.
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The IronChip evaluation package: a package of perl modules for robust analysis of custom microarrays
Yevhen Vainshtein,Mayka Sanchez,Alvis Brazma,Matthias W. Hentze,Thomas Dandekar,Martina U. Muckenthaler +5 more
TL;DR: The IronChip Evaluation Package (ICEP) is a collection of Perl utilities and an easy to use data evaluation pipeline for the analysis of microarray data with a focus on data quality of custom-designed microarrays.