Martina Seiffert
German Cancer Research Center
91 Papers
393 Citations
Martina Seiffert is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Chronic lymphocytic leukemia & Leukemia. The author has an hindex of 28, co-authored 77 publications. Previous affiliations of Martina Seiffert include University of Tübingen & Kobe University.
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Papers
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression
Ahmed Sadik,Luis F. Somarribas Patterson,Selcen Öztürk,Soumya R. Mohapatra,Verena Panitz,Philipp F Secker,Pauline Pfänder,Stefanie Loth,Heba Salem,Mirja Tamara Prentzell,Bianca Berdel,Murat Iskar,Erik Faessler,Friederike Reuter,Isabelle Kirst,Verena Kalter,Kathrin I. Foerster,Evelyn Jäger,Carina Ramallo Guevara,Mansour Sobeh,Thomas Hielscher,Gernot Poschet,Annekathrin Reinhardt,Jessica C. Hassel,Marc Zapatka,Udo Hahn,Andreas von Deimling,Carsten Hopf,Rita Schlichting,Beate I. Escher,Jürgen Burhenne,Walter E. Haefeli,Naveed Ishaque,Alexander Böhme,Sascha Schäuble,Kathrin Thedieck,Saskia Trump,Martina Seiffert,Christiane A. Opitz +38 more
TL;DR: A pan-tissue AHR signature revealed that across 32 tumor entities, interleukin-4-induced-1 (IL4I1) associates more frequently with AHR activity than IDO1 or TDO2, hitherto recognized as the main Trp-catabolic enzymes.
398
Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47.
Martina Seiffert,Charles Cant,Charles Cant,Charles Cant,Zhengjun Chen,Zhengjun Chen,Zhengjun Chen,Irene Rappold,Irene Rappold,Irene Rappold,Brugger W,Brugger W,Brugger W,Kanz L,Kanz L,Kanz L,Eric J. Brown,Eric J. Brown,Eric J. Brown,Axel Ullrich,Axel Ullrich,Axel Ullrich,Hans-Jörg Bühring,Hans-Jörg Bühring,Hans-Jörg Bühring +24 more
TL;DR: CD47 is identified as the extracellular ligand for human SIRP and it is shown that these two counterreceptors are involved in cellular adhesion.
311
Tumor-derived exosomes modulate PD-L1 expression in monocytes.
Franziska Haderk,Ralph Schulz,Murat Iskar,Laura Llao Cid,Thomas Worst,Karolin V. Willmund,Angela Schulz,Uwe Warnken,Jana Seiler,Axel Benner,Michelle Nessling,Thorsten Zenz,Maria Göbel,Jan Dürig,Sven Diederichs,Jérôme Paggetti,Etienne Moussay,Stephan Stilgenbauer,Marc Zapatka,Peter Lichter,Martina Seiffert +20 more
TL;DR: Exosome-mediated transfer of noncoding RNAs to monocytes contributes to cancer-related inflammation and concurrent immune escape via PD-L1 expression, and exosomal hY4 as a driver of TLR7 signaling is identified.
280
Signal-regulatory protein α (SIRPα) but not SIRPβ is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34+CD38- hematopoietic cells
Martina Seiffert,Peter Brossart,Peter Brossart,Peter Brossart,Charles Cant,Charles Cant,Charles Cant,Marina Cella,Marina Cella,Marina Cella,Marco Colonna,Marco Colonna,Marco Colonna,Wolfram Brugger,Wolfram Brugger,Wolfram Brugger,Lothar Kanz,Lothar Kanz,Lothar Kanz,Axel Ullrich,Axel Ullrich,Axel Ullrich,Hans-Jörg Bühring,Hans-Jörg Bühring,Hans-Jörg Bühring +24 more
TL;DR: The data suggest that the interaction of SIRPalpha with CD47 plays an important role during T-cell activation and induction of antigen-specific cytotoxic T-lymphocyte responses by DCs and analysis of the T-cells stimulatory capacity of in vitro generated DCs revealed a significant reduction of T- cell proliferation in mixed lymphocyte reaction and inhibition of induction of primary T- Cell responses under these conditions.
199
Cutting Edge: Signal-Regulatory Protein β1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells
TL;DR: It is shown that SIRPβ1 is a new DAP12-associated receptor involved in the activation of myeloid cells and associates with the signal transduction molecule DAP 12.
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